[1]吴隐雄 王小燕 张琴 赵毅兰 邓金龙 吴东峰 刘杰 廖钦晨 王舟 卢锋.培哚普利对老年轻中度高血压患者靶器官的保护作用[J].内科,2015,(05):597-600.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.05.01]
 WU Dong-feng,LIU Jie,LIAO Qin-chen,et al.Protective effect of perindopril on target organ in elderly patients with mild-to-moderate hypertension WU Yin-xiong1, WAN Xiao-yan2, ZHANG Qin3, ZHAO Yi-lan2, DENG Jin-long1,[J].Internal Medicine of China,2015,(05):597-600.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.05.01]
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培哚普利对老年轻中度高血压患者靶器官的保护作用()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2015年05期
页码:
597-600
栏目:
论著
出版日期:
2015-10-15

文章信息/Info

Title:
Protective effect of perindopril on target organ in elderly patients with mild-to-moderate hypertension WU Yin-xiong1, WAN Xiao-yan2, ZHANG Qin3, ZHAO Yi-lan2, DENG Jin-long1,
文章编号:
1673-7768(2015)05-0597-04
作者:
吴隐雄1 王小燕2 张琴3 赵毅兰2 邓金龙1 吴东峰1 刘杰1 廖钦晨1 王舟1 卢锋1
(1广西壮族自治区人民医院干部综合病房一区;2广西壮族自治区人民医院超声科;3广西壮族自治区人民医院心电诊断科,南宁市530021)
Author(s):
WU Dong-feng1 LIU Jie1 LIAO Qin-chen1 WANG Zhou1 LU Feng1
(1The first Integrated cadre ward, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530022, China; 2Department of Ultrasound, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530022, China; 3Department of Electrocardiogram diagnosis, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530022, China)
关键词:
培哚普利高血压颈动脉内-中膜厚度(IMT)肾功能心脏结构与功能
Keywords:
Perindopril Hypertension Artery intima media thickness Renal function Cardiac structure
分类号:
R 544.1
DOI:
DOI:10.16121/j.cnki.cn45-1347/r.2015.05.01
文献标志码:
A
摘要:
目的探讨培哚普利降压治疗对老年轻中度高血压患者颈动脉内-中膜厚度(IMT)、肾功能以及心脏结构与功能的影响。方法选取50例老年原发性轻中度高血压患者,经培哚普利(4~8 mg)治疗血压达标后,维持剂量治疗,随访0.5~1年。检测分析患者IMT、肾功能以及心脏结构和功能的变化情况。结果原发性轻中度高血压患者服用培哚普利半年后,收缩压显著下降(P<0.05);而治疗1年后,收缩压、舒张压均显著下降(P<0.05);脉压治疗前后比较差异无统计学意义(P>0.05);24 h动态血压(包括收缩压及舒张压)在治疗半年及一年后显著下降(P<0.01)。治疗半年、1年后,患者IMT明显降低(P均<0.05);尿β2微球蛋白(β2M)、微量白蛋白(mALB)、血肌酐显著下降(P均<0.01)。室间隔厚度(IVST)、左室后壁厚度(PWT)、二尖瓣最大舒张期血流测定E峰速度(PEV)、左心室重量指数(LVMI)和左室射血分数(EF)的均值治疗前后比较差异无统计学意义(P>0.05);治疗半年、1年后,患者二尖瓣最大舒张期血流测定A峰速度(PAV)明显低于治疗前(P<0.05);E/A比值显著升高(P均<0.01)。结论培哚普利治疗对原发性轻中度高血压患者的颈动脉IMT、肾功能以及心脏的舒张功能有明显改善作用。
Abstract:
ObjectiveTo observe the effect of perindopril on carotid artery intima media thickness (IMT), renal function, and cardiac structure and function in elderly patients with mild-to-moderate hypertension. MethodsFifty elderly patients with mild-to-moderate primary hypertension were enrolled and treated with perindopril (4~8 mg). The dosage of perindopril was maintained when the blood pressure met the requirements. All the patients were followed up for 0.5~1 year. The changes of IMT, renal function, and cardiac structure and function were recorded. ResultsAfter six-month treatment, systolic blood pressure significantly decreased (P<0.05). After one-year treatment, both systolic blood pressure and diastolic blood pressure significantly decreased (P<0.05). There was no significant difference in pulse pressure before and after treatment(P>0.05). 24h ambulatory systolic blood pressure (including systolic blood pressure and diastolic blood pressure) greatly decreased after six-month and one-year treatment (P<0.01). After six-month and one-year treatment, the IMT, Urinary β2 microglobulin (β2M), and albumin (ALB) significantly decreased (all P<0.05, all P<0.01, and all P<0.01). There were no significant differences in interventricular septum thickness (IVST), left ventricular posterior wall thickness (PWT), E-wave velocity measurement (PEV), and left ventricular ejection fraction (LVEF) before and after treatment. ConclusionsPerindopril can greatly improve carotid IMT, renal function and the diastolic function of heart in patients with mild-to-moderate primary hypertension.

参考文献/References:

[1]王文,朱曼璐,王拥军,等.心血管病已成为我国重要的公共卫生问题-《中国心血管病报告2011》概要[J].中国循环杂志,2012,27(6):409-411.
[2]刘力生.中国高血压防治指南2010[J]. 中华高血压杂志,2011,19(8):701-743.
[3]卢志红.国产拉西地平对广西轻中度原发性高血压50例患者24 h动态血压的影响[J].中国临床新医学,2011,4(9):838-840.
[4]蓝春勇,王小燕,凌冰,等.彩色多普勒超声对高血压糖尿病患者颈动脉粥样硬化的诊断价值[J].中国临床新医学,2009,2(12):1313-1315.
[5]艾丽菲热·买买提,陈红,任景怡.颈动脉内膜中层厚度在老年人群心脑血管事件中的评估价值[J].中华老年心脑血管病杂志,2012,14(6):619-621.
[6]Tropeano AI, Saleh N, Hawajri N, et al. Do all antihypertensive drugs improve carotid intima-media thickness? A network meta-analysis of randomized controlled trials[J]. Fundam Clin Pharmacol,2011,25(3):395-404.
[7]Napoli C,Bruzzese G,Ignarro LJ,et al.Long-term treatment with sulfhydryl angiotensin-converting enzyme inhibition reduces carotid intima-media thickening and improves the nitric oxide/oxidative stress pathways in newly diagnosed patients with mild to moderate primary hypertension[J]. Am Heart J,2008,156(6):1154.e1-e8.
[8]Poudel B,Yadav BK,Nepal AK,et al.Prevalence and association of microalbuminuria in essential hypertensive patients[J].N Am J Med Sci,2012,4(8):331-335.
[9]Ptinopoulou AG, Pikilidou MI, Lasaridis AN. The effect of antihypertensive drugs on chronic kidney disease:a comprehensive review[J].Hypertens Res,2013,36(2):91-101.
[10]陈望.单一或联合应用RAS阻断剂和钙离子拮抗剂对肾脏保护作用的比较研究[D].辽宁省:中国医科大学,2010.
[11]Nadruz W. Myocardial remodeling in hypertension[J]. J Hum Hypertens,2015,29(1):1-6.
 [12]高润霖,吴宁,胡大一,等.心血管病治疗指南和建议[M].北京:人民军医出版社,2005:141-142,154-155.
[13]Dahlof B,Gosse P,Gueret P,et al.Perindopril/indapamide combination more effective than enalapril in reducing blood pressure and left ventricular mass:the PICXEL study[J]. J Hypertens,2005,23(11):2063-2070.
[14]ADVANCE Echocardiography Substudy Investigators1, ADVANCE Collaborative Group. Effects of perindopril-indapamide on left ventricular diastolic function and mass in patients with type 2 diabetes: the ADVANCE Echocardiography Substudy[J]. J Hypertens,2011,29(7):1439-1447.

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备注/Memo

备注/Memo:
(收稿日期:2015-06-19修回日期:2015-08-16)
基金项目:广西医疗卫生重点科研课题(重200959)
更新日期/Last Update: 2015-10-28