[1]刘杰,吴东峰,廖钦晨,等.颈动脉粥样硬化斑块性质与血清总同型半胱氨酸、血脂水平的相关性研究▲[J].内科,2018,13(04):544-546.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2018.04.02]
 LIU Jie,WU Dongfeng,LIU Qinchen,et al.Correlation between carotid atherosclerotic vulnerable plaque and serum total homocysteine and blood lipid levels[J].Internal Medicine of China,2018,13(04):544-546.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2018.04.02]
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颈动脉粥样硬化斑块性质与血清总同型半胱氨酸、血脂水平的相关性研究▲()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
13卷
期数:
2018年04
页码:
544-546
栏目:
论著
出版日期:
2018-08-13

文章信息/Info

Title:
Correlation between carotid atherosclerotic vulnerable plaque and serum total homocysteine and blood lipid levels
文章编号:
1673-7768(2018)04-0544-03
作者:
刘杰吴东峰廖钦晨吴坚于坤
广西壮族自治区人民医院老年心血管病房,南宁市530021
Author(s):
LIU Jie WU Dongfeng LIU Qinchen WU Jian YU Kun
The People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
关键词:
颈动脉粥样硬化易损斑块同型半胱氨酸血脂相关性
Keywords:
Carotid atherosclerotic vulnerable plaque Homocysteine Blood lipids Correlation analysis
分类号:
R 543.4
DOI:
DOI:10.16121/j.cnki.cn45-1347/r.2018.04.02
文献标志码:
A
摘要:
目的探讨颈动脉粥样硬化斑块性质与血同型半胱氨酸(Hcy)、血脂水平的相关性。方法选取50岁以上进行颈部血管超声检查的颈动脉粥样硬化患者269例为研究对象,根据检查结果分为颈动脉粥样硬化稳定斑块组(简称稳定斑块组,106例)、颈动脉粥样硬化易损斑块组(简称易损斑块组,163例)。检测比较两组患者的血清Hcy水平、血脂水平;对影响易损斑块发生的因素进行多因素Logistic回归分析。结果易损斑块组患者的年龄、男性比例、TC、LDL-C、脂蛋白LP(a)、Hcy 水平高于稳定斑块组患者,HDL-C水平低于稳定斑块组患者,差异有统计学意义(P<0.05)。易损斑块组患者高同型半胱氨酸血症的比例显著高于稳定斑块组患者,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,高龄、高Hcy水平、高LP(a)水平是易损斑块发生的危险因素,女性、高HDL-C水平是易损斑块发生的保护因素。结论高龄、高Hcy水平、高LP(a)水平是颈动脉粥样硬化易损斑块发生的独立危险因素,降低Hcy水平对减缓颈动脉粥样硬化的进程可能具有积极的作用。
Abstract:
ObjectiveTo investigate the correlation between carotid atherosclerotic vulnerable plaque and blood homocysteine (Hcy) and blood lipid levels. MethodA total of 269 patients with carotid atherosclerosis who underwent cervical vascular ultrasonography were selected as subjects. According to the results, the carotid atherosclerotic stable plaque group (SP group, 106 cases) and the carotid atherosclerotic vulnerable plaque group (VP group, 163 cases) were selected. Serum Hcy levels and blood lipid levels were compared between the two groups. Multivariate logistic regression analysis was performed on the factors affecting the occurrence of vulnerable plaque. ResultsThe age, male ratio, TC, LDL-C, lipoprotein(a), and Hcy levels in the VP group were higher than those in the SP group, and the HDL-C was lower than that in the SP group. The difference was statistically significant (P<0.05). The proportion of patients with high homocysteinemia in the VP group was significantly higher than that in the SP group (P<0.05). Multivariate logistic regression analysis showed that age, high Hcy level and high LP(a) level were risk factors for vulnerable plaque. Female and high HDL-C levels were protective factors for vulnerable plaque. ConclusionAge, high Hcy level, and high LP(a) levels are risk factors for carotid atherosclerotic vulnerable plaque. HHcy is an independent risk factor for carotid vulnerable plaque formation. Lowering Hcy level reduces carotid atherosclerosis. The process of hardening may have a positive effect.

相似文献/References:

[1]林伟平.辛伐他汀治疗颈动脉粥样硬化斑块临床效果分析[J].内科,2013,(01):31.
 [J].Internal Medicine of China,2013,(04):31.
[2]许峰,梁科,赵伟,等.瑞舒伐他汀联合氨氯地平治疗对老年高血压合并颈动脉粥样硬化患者的血压及动脉硬化的影响▲[J].内科,2017,12(06):796.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2017.06.22]
 [J].Internal Medicine of China,2017,12(04):796.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2017.06.22]

备注/Memo

备注/Memo:
▲基金项目:广西壮族自治区卫生和计划生育委员会科研课题(Z2016591)
更新日期/Last Update: 2018-08-14