[1]张衡中,安玉东,屈蕾蕾,等.支气管镜肺灌洗治疗对稳定期慢性阻塞性肺疾病患者肺功能、生活质量以及血清炎性因子水平的影响▲[J].内科,2018,13(04):551-553+602.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2018.04.04]
 ZHANG Hengzhong,AN Yudong,QU Leilei,et al.Effect of bronchoscopy and lung lavage on pulmonary function, quality of life and serum inflammatory factors in patients with stable chronic obstructive pulmonary disease[J].Internal Medicine of China,2018,13(04):551-553+602.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2018.04.04]
点击复制

支气管镜肺灌洗治疗对稳定期慢性阻塞性肺疾病患者肺功能、生活质量以及血清炎性因子水平的影响▲()
分享到:

《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
13卷
期数:
2018年04
页码:
551-553+602
栏目:
论著
出版日期:
2018-08-13

文章信息/Info

Title:
Effect of bronchoscopy and lung lavage on pulmonary function, quality of life and serum inflammatory factors in patients with stable chronic obstructive pulmonary disease
文章编号:
1673-7768(2018)04-0551-04
作者:
张衡中安玉东屈蕾蕾达春和*
白银市第一人民医院呼吸科,甘肃省白银市730900
Author(s):
ZHANG Hengzhong AN Yudong QU Leilei DA Chunhe
Department of Respiratory, First People′s Hospital of Baiyin City, Baiyin, Gansu Province 730900, China
关键词:
慢性阻塞性肺疾病支气管镜肺灌洗肺功能生活质量
Keywords:
Chronic obstructive pulmonary disease Bronchoscopy Lung lavage Lung function Quality of life
分类号:
R 562
DOI:
DOI:10.16121/j.cnki.cn45-1347/r.2018.04.04
文献标志码:
A
摘要:
目的探讨支气管镜肺灌洗治疗对稳定期慢性阻塞性肺疾病患者肺功能、生活质量以及炎性因子水平的影响。方法选取2015年2月至2017年10月在白银市第一人民医院诊治的稳定期慢性阻塞性肺疾病患者74例为研究对象,随机分为对照组与观察组,每组37例。对照组患者给予家庭氧疗和布地奈德/福莫特罗吸入治疗,观察组患者在对照组治疗的基础上行支气管镜肺灌洗术治疗。检测比较两组患者灌洗前、灌洗后1周的肺功能、血清炎症因子水平、生活质量。结果灌洗治疗1周后,观察组患者FEV1%、FEV1/FVC显著高于灌洗前及对照组,血清白介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)、干扰素γ(IFN-γ)、结缔组织生长因子(CTGF)水平显著低于灌洗前及对照组,MRC评分低于灌洗前及对照组,ADL(Barthel)评分显著高于灌洗前及对照组,差异有统计学意义(P<0.01)。结论对稳定期慢性阻塞性肺疾病患者,在给予家庭氧疗和布地奈德/福莫特罗吸入治疗的基础上给予支气管镜肺灌洗治疗,可以有效改善肺功能、减轻气道炎症和全身性炎症反应,延缓病情进展,提高生活质量。
Abstract:
ObjectiveTo investigate the effects of bronchoscopy and lung lavage on lung function, quality of life and inflammatory factors in patients with stable chronic obstructive pulmonary disease. Methods74 patients with stable chronic obstructive pulmonary disease diagnosed at the First People’s Hospital of Baiyin from February 2015 to October 2017 were randomly divided into the control group and the observation group, with 37 cases in each group. Patients in the control group were treated with home oxygen therapy and budesonide/formoterol, and the patients in the observation group were treated with basal bronchial lung lavage in the control group. The lung function, serum inflammatory factor levels and quality of life were compared between the two groups before and after lavage. ResultsAfter 1 week of lavage treatment, FEV1% and FEV1/FVC were significantly higher in the observation group than before lavage and control group, serum interleukin-1β (IL-1β), tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), connective tissue growth factor (CTGF) levels were significantly lower than before lavage and control group, MRC score was lower than before lavage and control group, ADL (Barthel) score was significantly higher than before lavage and control group, the difference was Statistical significance (P<0.01). ConclusionAdministration of home oxygen therapy and budesonide/formoterol treatment and bronchoscopy lung lavage in patients with stable chronic obstructive pulmonary disease can effectively improve lung function, reduce airway inflammation and systemic inflammatory response, delay the progression of the disease, and improve the quality of life.

相似文献/References:

[1]覃淑娟,陈昌枝,冯洁美,等.慢性阻塞性肺疾病患者血浆醛固酮的表达特征[J].内科,2014,(05):517.
 QIN Shu juan,CHEN Chang zhi,FENG Jie mei,et al.Characterristics of plasma aldosterone in patients with chronic obstructive pulmonary[J].Internal Medicine of China,2014,(04):517.
[2]杨瑾,李桂娟,常丽霞,等.慢性阻塞性肺疾病急性加重期和缓解期患者C反应蛋白检测结果分析[J].内科,2014,(05):564.
[3]邵有和,陈昌枝,冯洁美,等.慢性阻塞性肺疾病中炎症细胞、细胞因子与肺功能的关系[J].内科,2014,(05):597.
[4]陆红梅 朱春燕 包守丽.多功能无创正压通气治疗COPD并发肺性脑病的疗效观察[J].内科,2015,(01):31.[doi:03DOI:10.16121/j.cnki.cn45-1347/r.2015.01.13]
 [J].Internal Medicine of China,2015,(04):31.[doi:03DOI:10.16121/j.cnki.cn45-1347/r.2015.01.13]
[5]荣蓉 蔡孝桢 周寅川 尹成红 曾莉莉 袁钻云.慢性阻塞性肺疾病不同营养状况患者白介素-6检测结果分析[J].内科,2015,(02):205.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.02.26]
[6]何旭林 王海英 张芳 马桂兰 张彩平 张国莲.临夏市慢性阻塞性肺疾病合并慢性肺源性心脏病急性加重期患者病原菌分析[J].内科,2015,(02):207.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.02.27]
 [J].Internal Medicine of China,2015,(04):207.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.02.27]
[7]黄维.有创-无创序贯机械通气治疗COPD合并呼吸衰竭患者疗效分析[J].内科,2015,(03):310.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.03.10]
 [J].Internal Medicine of China,2015,(04):310.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.03.10]
[8]陈锋 郑志宏 程明照.慢性阻塞性肺疾病合并社区获得性肺炎50例病原菌及其耐药性分析[J].内科,2015,(04):504.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.04.26]
 [J].Internal Medicine of China,2015,(04):504.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.04.26]
[9]秦小雯.无创正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭疗效预测研究进展[J].内科,2015,(04):554.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.04.47]
 [J].Internal Medicine of China,2015,(04):554.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.04.47]
[10]沈智姹.认知行为护理干预对慢性阻塞性肺疾病患者自我护理能力及生活质量的影响[J].内科,2015,(04):577.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.04.56]
 [J].Internal Medicine of China,2015,(04):577.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.04.56]
[11]张衡中,安玉东,达春和.支气管镜肺灌洗治疗稳定期慢性阻塞性肺疾病患者的有效性和安全性研究▲[J].内科,2018,13(02):166.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2018.02.07]
 ZHANG Hengzhong,AN Yudong,DA Chunhe*.The efficacy and safety of bronchoscopic lung lavage in the treatment of patients with stable chronic obstructive pulmonary disease[J].Internal Medicine of China,2018,13(04):166.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2018.02.07]

备注/Memo

备注/Memo:
▲基金项目:白银市科学技术局项目(2013-2-58Y)
*通信作者
更新日期/Last Update: 2018-08-14