[1]王金莉,陈杰明,李金贵,等.亚低温联合右美托咪定治疗心肺复苏后缺血缺氧性脑病患者的临床研究▲[J].内科,2018,13(04):554-556.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2018.04.05]
 WANG Jinli,CHEN Jieming,LI Jingui,et al.Clinical study of mild hypothermia combined with dexmedetomidine in the treatment of patients with hypoxic ischemic encephalopathy after cardiopulmonary resuscitation[J].Internal Medicine of China,2018,13(04):554-556.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2018.04.05]
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亚低温联合右美托咪定治疗心肺复苏后缺血缺氧性脑病患者的临床研究▲()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
13卷
期数:
2018年04
页码:
554-556
栏目:
论著
出版日期:
2018-08-13

文章信息/Info

Title:
Clinical study of mild hypothermia combined with dexmedetomidine in the treatment of patients with hypoxic ischemic encephalopathy after cardiopulmonary resuscitation
文章编号:
1673-7768(2018)04-0554-03
作者:
王金莉陈杰明李金贵林合麟*
深圳市宝安区中心医院重症医学科,深圳市518000
Author(s):
WANG Jinli CHEN Jieming LI Jingui LIN Helin
Critical medical department, Bao′an District Central Hospital, Shenzhen, Shenzhen 518000, China
关键词:
心肺复苏缺血缺氧性脑病治疗亚低温右美托咪定
Keywords:
Cardiopulmonary resuscitation Hypoxic ischemic encephalopathy Hypothermia Dexmedetomidine
分类号:
R 541.78
DOI:
DOI:10.16121/j.cnki.cn45-1347/r.2018.04.05
文献标志码:
A
摘要:
目的探讨亚低温联合右美托咪定治疗心肺复苏后缺血缺氧性脑病患者的临床效果,为临床治疗提供参考。方法选取2016年8月至2017年12月我院收治的心搏骤停心肺复苏后自主循环恢复并持续昏迷的患者80例为研究对象,随机为成研究组和对照组各40例。对照组患者在基础治疗的基础上采用亚低温治疗72 h;研究组患者在对照组治疗的基础上加用右美托咪定静脉滴注治疗5 d。比较两组患者入院即刻、入院第5天、第10天的神经元特异性烯醇化酶水平;比较两组患者的意识恢复、反射恢复和肌张力恢复时间。结果入院即刻,两组患者的神经元特异性烯醇化酶水平比较差异无统计学意义(P>0.05);治疗第5天和第10天,研究组患者的神经元特异性烯醇化酶水平显著低于对照组,差异有统计学意义(P<0.01)。研究组患者的意识恢复、反射恢复和肌张力恢复时间均明显短于对照组,差异有统计学意义(P<0.01)。结论亚低温联合右美托咪定治疗心肺复苏后缺血缺氧性脑病患者,能更有效地降低患者血清神经元特异性烯醇化酶水平,缩短患者意识恢复、反射恢复和肌张力恢复时间,促进患者康复,改善患者预后。
Abstract:
ObjectiveTo explore the clinical effect of mild hypothermia combined with dexmedetomidine in patients with hypoxic ischemic encephalopathy after cardiopulmonary resuscitation, and provide reference for clinical treatment. Methods88 patients with spontaneous circulation recovery and continuous coma after cardiopulmonary resuscitation from August 2016 to December 2017 were selected as subjects. They were randomly divided into study group and control group, 40 cases each. The patients in the control group were treated with mild hypothermia for 72 hours on the basis of basic treatment. Patients in the study group were treated with dexmedetomidine intravenously for 5 days on the basis of treatment in the control group. The neuron-specific enolase levels were compared between the two groups immediately after admission, on the 5th day and the 10th day after admission. The recovery of consciousness, the recovery of reflexes, and the recovery time of muscle tone were compared between the two groups. ResultsImmediately after admission, there was no significant difference in neuron-specific enolase levels between the two groups (P>0.05). On the 5th and 10th day of treatment, the neuron-specific enolase levels in the study group were significantly lower than those in the control group, and the difference was statistically significant (P<0.01). The recovery of consciousness, recovery of reflex and recovery time of muscle tone in the study group were significantly shorter than those in the control group, and the difference was statistically significant (P<0.01). ConclusionMild hypothermia combined with dexmedetomidine in patients with hypoxic ischemic encephalopathy after cardiopulmonary resuscitation can more effectively reduce serum neuron-specific enolase levels, shorten patient recovery, reflex recovery and muscle tension recovery time, promote the patient recovers and improves the prognosis of the patient.

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备注/Memo

备注/Memo:
▲基金项目:2016深圳市宝安区卫生科研项目(2016CX056)
*通信作者
更新日期/Last Update: 2018-08-14