[1]邓姗姗,朱明志,李拔敏.腹膜透析联合血液透析治疗腹膜透析不充分患者的临床研究[J].内科,2018,13(04):578-580+644.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2018.04.12]
 DENG Shanshan,ZHU Mingzhi,LI Bamin.Clinical investigation of peritoneal dialysis combined with hemodialysis in treatment of patients with inadequate peritoneal dialysis[J].Internal Medicine of China,2018,13(04):578-580+644.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2018.04.12]
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腹膜透析联合血液透析治疗腹膜透析不充分患者的临床研究()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
13卷
期数:
2018年04
页码:
578-580+644
栏目:
论著
出版日期:
2018-08-13

文章信息/Info

Title:
Clinical investigation of peritoneal dialysis combined with hemodialysis in treatment of patients with inadequate peritoneal dialysis
文章编号:
1673-7768(2018)04-0578-04
作者:
邓姗姗朱明志李拔敏
高州市人民医院肾内科,广东省高州市525200
Author(s):
DENG Shanshan ZHU Mingzhi LI Bamin
Department of Nephrology,The People’s Hospital of Gaozhou,Gaozhou 525200,China
关键词:
终末期肾病腹膜透析血液透析肾功能
Keywords:
End-stage renal disease Peritoneal dialysis Hemodialysis Renal function
分类号:
R 692
DOI:
DOI:10.16121/j.cnki.cn45-1347/r.2018.04.12
文献标志码:
A
摘要:
目的探讨腹膜透析联合血液透析在终末期肾病腹膜透析不充分患者中的应用价值。方法选取2016年4月至2017年9月我院进行透析治疗的终末期肾病患者46例为研究对象,按照随机数字表法分为对照组和观察组,每组23例。对照组患者通过加大腹膜透析剂量进行治疗,观察组患者在原腹膜透析剂量治疗的基础上联合血液透析治疗。比较两组患者的临床治疗效果;检测比较治疗前后两组患者的肾功能相关指标、炎性因子水平和免疫功能状态以及相关并发症的发生情况。结果治疗3个月后,观察组患者的治疗总有效率(91.30%)显著高于对照组(65.22%),差异有统计学意义(P<0.05);两组患者的BUN、Scr水平均显著降低,观察组患者的尿素氮(BUN)、血肌酐(Scr)水平显著低于对照组,差异有统计学意义(P<0.01);两组患者血清TNF-α、IL-6、 IgG、IgA、IgM水平均显著降低,观察组患者的各指标的水平均显著低于对照组,差异有统计学意义(P<0.05)。治疗期间,观察组患者的并发症发生率(4.35%)明显低于对照组(26.09%),差异有统计学意义(P<0.05)。结论对腹膜透析不充分的终末期肾病患者进行腹膜透析联合血液透析治疗,可有效提高治疗效果,保护残余肾功能,缓解炎症反应,提高免疫功能,降低相关并发症的发生率。
Abstract:
ObjectiveTo investigate the application values of peritoneal dialysis combined with hemodialysis in treatment of patients with end-stage renal disease and inadequately peritoneal dialysis. MethodsA total of 46 cases of end-stage renal disease patients with inadequately peritoneal dialysis admitted to our hospital from April 2016 to September 2017 were selected as the research subjects and divided into control group and observation group by the random digital table method,with 23 cases in each group.The control group were increased the dose of peritoneal dialysis,while the observation group were combined with hemodialysis on the basis of the primary peritoneal dialysis dose.Compared with clinical efficacy,renal function index,inflammatory cytokine levels,immunological function status and adverse reactions between two groups. ResultsAfter 3 mouth treatment,total therapeutic efficiency of observation group (91.30%)was significantly higher than that in the control group (65.22%),with statistical significance(P<0.05).The levels of BUN,Scr were significantly decreased in both groups,and those in the observation group were lower than control group,with statistical significance(P<0.01).The levels of TNF-α,IL-6,IgG,IgA,IgM were significantly decreased in both groups,and those in the observation group were lower than control group,with statistical significance (P<0.05).During the duration of therapy,the incidence of complications in observation group (4.35%) was significantly lower than control group, (36.09%),with statistical significance (P<0.05). ConclusionThe peritoneal dialysis combined with hemodialysis could effectively improve the treatment effect of insufficient peritoneal dialysis patients, protect the residual renal function,mitigate inflammatory reaction and improve immune function,reduce the incidence of related complications.

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更新日期/Last Update: 2018-08-14