[1]屈蕾蕾,边雨田,张衡中*.厄多司坦联合支气管镜下肺泡灌洗治疗老年支气管扩张合并感染患者的疗效及对血清炎性因子水平的影响[J].内科,2018,13(04):588-591+632.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2018.04.15]
 QU Leilei,BIAN Yutian,ZHANG Hengzhong.Efficacy of erdosteine combined with bronchoscope alveolar lavage in treating patients with senile bronchiectasis complicated with infection and its effects on levels of serum inflammatory cytokine[J].Internal Medicine of China,2018,13(04):588-591+632.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2018.04.15]
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厄多司坦联合支气管镜下肺泡灌洗治疗老年支气管扩张合并感染患者的疗效及对血清炎性因子水平的影响()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
13卷
期数:
2018年04
页码:
588-591+632
栏目:
论著
出版日期:
2018-08-13

文章信息/Info

Title:
Efficacy of erdosteine combined with bronchoscope alveolar lavage in treating patients with senile bronchiectasis complicated with infection and its effects on levels of serum inflammatory cytokine
文章编号:
1673-7768(2018)04-0588-05
作者:
屈蕾蕾边雨田张衡中*
白银市第一人民医院呼吸科,甘肃省白银市730900
Author(s):
QU Leilei BIAN Yutian ZHANG Hengzhong
Department of Respiration,The 1st People′s Hospital of Baiyin,Baiyin 730900,China
关键词:
支气管扩张症感染老年人治疗厄多司坦肺泡灌洗
Keywords:
BronchiectasisInfectionOld peopleTreatmentErdosteineBronchoalveolar lavage
分类号:
R 562.2
DOI:
DOI:10.16121/j.cnki.cn45-1347/r.2018.04.15
文献标志码:
A
摘要:
目的观察厄多司坦联合支气管镜下肺泡灌洗治疗老年支气管扩张合并感染患者的疗效及对血清炎性因子水平的影响。方法将老年支气管扩张合并感染患者72例随机分为两组,每组36例,对照组患者在常规抗感染治疗基础上给予支气管镜下肺泡灌洗治疗;观察组在对照组治疗的基础上联合厄多司坦治疗。比较两组患者的临床疗效、肺功能、痰液性状评分、炎性因子水平以及不良反应发生情况。结果治疗10 d后,观察组患者的治疗总有效率(88.9%)显著高于对照组(63.9%),差异有统计学意义(P<0.05);两组患者的FEV1、FVC、PEF、MIP、MEP、PaO2、PaCO2均显著改善,观察组患者FEV1、FVC、PEF、MIP、MEP、PaO2的改善情况均显著优于对照组(P<0.05);两组患者的MD、MP显著降低、MVP评分显著升高,观察组MD、MP评分均低于对照组、MVP评分显著高于对照组,差异有统计学意义(均P<0.05);两组患者的hs-CRP、IL-10、TNF-α水平显著降低,观察组患者的hs-CRP、IL-10、TNF-α水平均显著低于对照组(P<0.05)。观察组患者的不良反应发生率(11.1%)显著低于对照组(36.1%),差异有统计学意义(P<0.05)。结论厄多司坦联合支气管镜下肺泡灌洗治疗老年支气管扩张合并感染患者临床疗效显著,能有效降低患者的炎症因子水平、改善患者的肺功能和临床症状、降低不良反应的发生率。
Abstract:
ObjectiveTo observe the effect of erdosteine combined with bronchoscope alveolar lavage in treating patients with senile bronchiectasis complicated with infection and its effects on levels of serum inflammatory cytokine. MethodsA total of 72 patients with bronchiectasis complicated with infection were randomly divided into 2 groups,with 36 cases in each group.Control group patients were given bronchoscope alveolar lavage treatment on the basis of anti-infection treatment,while the observation group were added with erdosteine treatment on the basis of treatment of control group.Compared with clinical efficacy,pulmonary function,sputum score,inflammatory cytokine levels and adverse reactions between two groups. ResultsAfter 10 days treatment,total therapeutic efficiency of observation group (88.9%)was significantly higher than that in the control group (63.9%),with statistical significance(P<0.05).The levels of FEV1,FVC,PEF,MIP,MEP,PaO2,PaCO2 were significantly improved in both groups,and those in the observation group were better than control group (P<0.05).The scores of MD,MP were significantly decreased,MVP was significantly increased in both groups,and the MD,MP scores in observation group was significantly lower than those in control group,the MVP score of observation group was significantly higher than that in control group,with statistical significance (all P<0.05).The levels of hs-CRP, IL-10, TNF-α were significantly decreased in both groups,and those in the observation group were significantly lower than control group (P<0.05).The total incidence of adverse reaction in observation group (11.1%)was lower than control group (36.1%),with statistical significance (P<0.05). ConclusionErdosteine combined with bronchoscopic bronchoalveolar lavage in treatment of senile bronchiectasis complicated with infection has significant clinical curative effect,which could significantly reduce inflammatory cytokine levels,improve pulmonary function and clinical symptoms,reduce adverse reaction rate.

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更新日期/Last Update: 2018-08-14