[1]王玉珠,曹爱春,温菊霞.甘草酸二铵联合丙种球蛋白治疗小儿急性重症病毒性心肌炎的疗效分析[J].内科,2018,13(04):603-605+550.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2018.04.19]
 WANG Yuzhu,CAO Aichun,WEN Juxia.Efficacy analysis of diammonium glycyrrhizinate combined with gamma globulin in treatment of children with acute severe viral myocarditis[J].Internal Medicine of China,2018,13(04):603-605+550.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2018.04.19]
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甘草酸二铵联合丙种球蛋白治疗小儿急性重症病毒性心肌炎的疗效分析()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
13卷
期数:
2018年04
页码:
603-605+550
栏目:
论著
出版日期:
2018-08-13

文章信息/Info

Title:
Efficacy analysis of diammonium glycyrrhizinate combined with gamma globulin in treatment of children with acute severe viral myocarditis
文章编号:
1673-7768(2018)04-0603-04
作者:
王玉珠曹爱春温菊霞
定西市人民医院,甘肃省定西市743000
Author(s):
WANG YuzhuCAO AichunWEN Juxia
Dingxi People’s Hospital,Gansu 743000,China
关键词:
小儿急性重症病毒性心肌炎治疗甘草酸二铵注射液大剂量丙种球蛋白
Keywords:
Acute severe viral myocarditis in childrenTreatmentDiammonium glycyrrhizinate injectionLarge dose of gamma globulin
分类号:
R 542.2
DOI:
DOI:10.16121/j.cnki.cn45-1347/r.2018.04.19
文献标志码:
A
摘要:
目的观察甘草酸二铵注射液联合大剂量丙种球蛋白治疗小儿急性重症病毒性心肌炎的疗效。方法将108例小儿急性重症病毒性心肌炎患儿随机分为对照组和研究组,每组54例。对照组患儿给予大剂量丙种球蛋白治疗,研究组患儿给予甘草酸二铵注射液联合大剂量丙种球蛋白治疗。比较两组患儿的临床疗效;检测比较两组患儿治疗前后血清白细胞介素-8(IL-8)、白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)水平和肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)及肌酸激酶(CK)水平;观察比较两组患儿治疗期间的不良反应发生情况。结果治疗14 d后,研究组患儿的治疗总有效率(96.3%)显著高于对照组(81.5%),差异有统计学意义(P<0.05);两组患儿的IL-8、IL-17及TNF-α水平以及CK-MB、LDH及CK水平均显著下降,研究组患儿上述指标水平均显著低于对照组,差异有统计学意义(P<0.05)。治疗过程中两组患儿的不良反应发生率比较差异无统计学意义(P>0.05)。结论甘草酸二铵注射液联合大剂量丙种球蛋白治疗小儿急性重症病毒性心肌炎患儿能取得较好的临床疗效,有效缓解心肌细胞炎症反应,纠正免疫功能紊乱,促进患儿康复。
Abstract:
ObjectiveTo observe the effect of diammonium glycyrrhizinate injection combined with large dose of gamma globulin in treatment of children with acute severe viral myocarditis. MethodsA total of 108 children with acute severe viral myocarditis were randomly divided into control group and study group,with 54 cases in each group.The control group were treated with large dose of gamma globulin,while the study group were treated with diammonium glycyrrhizinate injection combined with large dose of gamma globulin.The clinical efficacy of two groups were compared,the levels of serum interleukin-8 (IL-8),interleukin-17 (IL-17),tumor necrosis factor-alpha (TNF-α) and creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH) and creatine kinase (CK) were detected and compared before and after treatment between the two groups.The adverse reactions were observed and compared between two groups. ResultsAfter 14 days treatment,the total effective rate of study group (96.3%) was significantly higher than that of control group (81.5%),with statistical significance (P<0.05).The serum levels of IL-8, IL-17,TNF-α and CK-MB, LDH,CK in two groups were significantly lower than those before treatment (P<0.05),the above indexes in study group were significantly lower than those in the control group,with statistical significance (P<0.05).There was no significant difference in the incidence of adverse reactions between two groups in the course of treatment (P>0.05). ConclusionDiammonium glycyrrhizinate injection combined with large dose of gamma globulin is effective in the treatment of acute severe viral myocarditis in children,it can significantly relieve the inflammation of myocardial cells,correct immune dysfunction and promote the recovery of children.

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更新日期/Last Update: 2018-08-14