[1]陈昭霞,龙建雄,郭晓婧,等.MAPK1基因多态性及mRNA表达与缺血性脑卒中神经功能缺损程度的相关分析▲[J].内科,2019,14(02):125-128+141.[doi:10.16121/j.cnki.cn45-1347/r.2019.02.01]
 CHEN Zhaoxia,LONG Jianxiong,GUO Xiaojing,et al.Correlation between MAPK1 gene polymorphisms and mRNA expression and the degree of neurological deficits in patients with ischemic stroke[J].Internal Medicine of China,2019,14(02):125-128+141.[doi:10.16121/j.cnki.cn45-1347/r.2019.02.01]
点击复制

MAPK1基因多态性及mRNA表达与缺血性脑卒中神经功能缺损程度的相关分析▲()
分享到:

《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
14卷
期数:
2019年02
页码:
125-128+141
栏目:
论著
出版日期:
2019-04-30

文章信息/Info

Title:
Correlation between MAPK1 gene polymorphisms and mRNA expression and the degree of neurological deficits in patients with ischemic stroke
文章编号:
1673-7768(2019)02-0125-05
作者:
陈昭霞龙建雄郭晓婧黄焦杨佳磊朱路路吴旭龙苏莉*
广西医科大学公共卫生学院流行病学教研室,南宁市530021
Author(s):
CHEN Zhaoxia LONG Jianxiong GUO Xiaojing HUANG Jiao YANG Jialei ZHU Lulu WU Xulong SU Li
Department of Epidemiology, School of Public Health, Guangxi Medical University, Nanning 530021, China
关键词:
缺血性脑卒中MAPK1基因单核苷酸多态性mRNA表达NIHSS评分
Keywords:
Ischemic stroke MAPK1 gene Single nucleotide polymorphism mRNA expression NIHSS score
分类号:
R 543.5;R 743.3
DOI:
10.16121/j.cnki.cn45-1347/r.2019.02.01
文献标志码:
A
摘要:
目的探讨丝裂原活化蛋白激酶1(MAPK1)基因rs6928、rs13515、rs1063311多态性及MAPK1基因mRNA表达与缺血性脑卒中(IS)患者神经功能缺损严重程度的相关性。方法采用Massarray SNP基因分型技术对MAPK1基因的rs6928、rs13515、rs1063311多态性进行基因分型,运用qRT-PCR实验技术测定MAPK1基因mRNA表达水平,使用NIHSS量表对IS患者进行神经功能缺损评分。结果校正性别、年龄之后,在加性模型、隐性模型中,rs6928多态性与IS患者NIHSS评分具有相关性(P<0.05)。MAPK1基因mRNA表达水平与IS患者NIHSS评分无相关性(P>0.05)。结论MAPK1基因rs6928多态性可能会影响IS患者神经功能缺损的严重程度。
Abstract:
ObjectiveTo investigate the correlation between polymorphisms of mitogen-activated protein kinases 1(MAPK1)gene rs6928, rs13515 and rs1063311 and MAPK1 mRNA expression and the degree of neurological deficits in patients with ischemic stroke(IS). MethodsGenotypes of MAPK1 gene rs6928, rs13515 and rs1063311 were detected using Massarray SNP genotyping technique, MAPK1 mRNA expression was assessed by qRT-PCR, and the degree of neurological deficits in patients with IS was evaluated using NIHSS score. ResultsAfter adjusting for gender and age, the polymorphisms of rs6928 was associated with NIHSS score in patients with IS in the additive model and recessive model(P<0.05). The MAPK1 mRNA expression was not correlated to NIHSS score in IS patients (P>0.05). ConclusionThe polymorphism of MAPK1 gene rs6928 may affect the degree of neurological deficits in patients with IS.

相似文献/References:

[1]罗杰峰.神经干细胞移植治疗缺血性脑卒中研究进展▲[J].内科,2012,(05):528.
 [J].Internal Medicine of China,2012,(02):528.
[2]杜福文.他汀类药物防治缺血性脑卒中的研究进展[J].内科,2010,(01):58.
 [J].Internal Medicine of China,2010,(02):58.
[3]黄智武,徐家志,谢杰,等.合浦县缺血性脑卒中患者颈内动脉粥样硬化检测分析[J].内科,2010,(03):274.
 [J].Internal Medicine of China,2010,(02):274.
[4]王英兆.门诊缺血性卒中患者抗血小板聚集治疗临床分析[J].内科,2016,(01):58.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2016.01.20]
 [J].Internal Medicine of China,2016,(02):58.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2016.01.20]
[5]刘刚,李安民,郭颖莹,等.缺血性脑卒中脑血管狭窄支架治疗临床效果观察[J].内科,2016,(02):227.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2016.02.20]
 [J].Internal Medicine of China,2016,(02):227.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2016.02.20]
[6]卢运康.缺血性脑卒中患者抗栓治疗现状及基层医师相关知识、态度和行为对治疗依从性的影响▲[J].内科,2016,(06):869.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2016.06.17]
 [J].Internal Medicine of China,2016,(02):869.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2016.06.17]
[7]王文芳.丁苯酞软胶囊治疗缺血性脑卒中患者的疗效及对侧支循环血流及神经功能的影响[J].内科,2018,13(02):224.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2018.02.24]
 [J].Internal Medicine of China,2018,13(02):224.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2018.02.24]
[8]王学良.通窍活络化痰逐瘀汤配合针灸治疗缺血性脑卒中患者的疗效及对神经功能和血清MMP-2、MDA、VEGF水平的影响[J].内科,2018,13(06):856.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2018.06.13]
 [J].Internal Medicine of China,2018,13(02):856.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2018.06.13]

备注/Memo

备注/Memo:
▲基金项目:国家自然科学基金项目(81473670,81573756)
*通信作者:苏莉,广西医科大学公共卫生学院流行病学教研室,电子邮箱 suli2018@hotmail.com
更新日期/Last Update: 2019-05-09