[1]郭辉,魏斐斐,蒋群湘,等.TAGLN2基因单核苷酸多态性与广西扶绥县肝癌高发家系遗传易感性的关系▲[J].内科,2019,14(02):142-145.[doi:10.16121/j.cnki.cn45-1347/r.2019.02.05]
 GUO Hui,WEI Feifei,JIANG Qunxiang,et al.Relationship between single nucleotide polymorphism of TAGLN2 gene and genetic susceptibility of hepatocellular carcinoma families in Fusui County, Guangxi[J].Internal Medicine of China,2019,14(02):142-145.[doi:10.16121/j.cnki.cn45-1347/r.2019.02.05]
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TAGLN2基因单核苷酸多态性与广西扶绥县肝癌高发家系遗传易感性的关系▲()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
14卷
期数:
2019年02
页码:
142-145
栏目:
论著
出版日期:
2019-04-30

文章信息/Info

Title:
Relationship between single nucleotide polymorphism of TAGLN2 gene and genetic susceptibility of hepatocellular carcinoma families in Fusui County, Guangxi
文章编号:
1673-7768(2019)02-0142-04
作者:
郭辉1魏斐斐2蒋群湘3谢裕安1*
1 广西医科大学附属肿瘤医院,南宁市530021;2 桂林市人民医院,广西桂林市541002;3 柳州市人民医院,广西柳州市545006
Author(s):
GUO Hui1 WEI Feifei2 JIANG Qunxiang3 XIE Yu′an1
1 Guangxi Medical University Affiliated Tumor Hospital, Nanning 530021,China; 2 Guilin People′s Hospital, Guilin 541002, China; 3 Liuzhou General Hospital, Liuzhou 545006, China
关键词:
肝细胞癌TAGLN2基因单核苷酸多态性遗传易感性
Keywords:
Hepatocellular carcinoma TAGLN2 gene Single nucleotide polymorphism Genetic susceptibility
分类号:
R 735.7
DOI:
10.16121/j.cnki.cn45-1347/r.2019.02.05
文献标志码:
A
摘要:
目的探讨TAGLN2基因rs2252815和rs2789422位点单核苷酸多态性与广西扶绥县原发性肝细胞癌(以下简称“肝癌”)高发家系遗传易感性的关系。方法选取广西扶绥县20个肝癌高发家系成员共79例,将其中肝癌患者20例设为肝癌高发家系肝癌组,将无肝癌的直系亲属成员59例设为肝癌高发家系非肝癌组;将10个正常对照家系的成员40例设为正常家系对照组。采用飞行时间质谱技术检测TAGLN2基因rs2252815和rs2789422位点的基因型和等位基因频率;采用非条件Logistic回归分析三组人群等位基因及基因型分布频率的差异。结果TAGLN2基因rs2252815位点存在CC、CT和TT三种基因型,其中CC基因型19例、CT基因型47例、TT基因型51例(2例未检测出相应基因型);rs2789422位点存在CC、CT和TT三种基因型,其中CC基因型72例、CT基因型43例、TT基因型3例(1例未检测出相应基因型)。肝癌高发家系肝癌组与肝癌高发家系非肝癌组或正常家系对照组进行比较,TAGLN2基因rs2252815和rs2789422位点CC、CT、TT基因型及等位基因C、T分布频率比较差异均无统计学意义(P>0.05)。结论TAGLN2基因rs2252815和rs2789422位点单核苷酸多态性与广西扶绥县肝癌家系遗传易感性之间无明显相关性。
Abstract:
ObjectiveTo investigate the relationship between single nucleotide polymorphisms of TAGLN2 gene rs2252815 and rs2789422 and the genetic susceptibility of hepatocellular carcinoma families in Fusui County, Guangxi. MethodsA total of 79 cases from high incidence of liver cancer families were selected in Fusui County, Guangxi. 20 cases with hepatocellular carcinoma were set as hepatocarcinoma group, 59 cases without hepatocellular carcinoma were set as non-hepatocarcinoma group. 10 normal control families (40 cases) were set as normal family control group. The genotype and allele frequency distribution of TAG225N15 gene rs2252815 and rs2789422 were detected by time-of-flight mass spectrometry. Unconditional logistic regression was used to analyze the difference of genotype and allele frequency distribution among the three groups. ResultsThree genotypes of CC, CT and TT were identified in the locus rs2252815 of TAGLN2 gene, including 19 cases of CC genotype, 47 cases of CT genotype and 51 cases of TT genotype (2 cases were not identified corresponding genotype). Three genotypes of CC, CT and TT were identified in the locus rs2789422, including 72 cases of CC genotype, 43 cases of CT genotype and 3 cases of TT genotype (1 case was not identified corresponding genotype). There were not statistically significant in frequencies of CC, CT, TT genotype and allele C and T distribution at locus rs2252815 and rs2789422 of TAGLN2 gene between hepatocarcinoma group and non-hepatocarcinoma group or the normal family control group. ConclusionThere is no significant correlation between the single nucleotide polymorphisms at locus rs2252815 and rs2789422 of TAGLN2 gene and the genetic susceptibility of hepatocellular carcinoma families in Fusui Country, Guangxi.

相似文献/References:

[1]王林金,吴健林,吴继周,等.Caveolin-1和Caspase-3蛋白在肝细胞癌中的表达及意义▲[J].内科,2012,(06):579.
 WANG Lin-jin,WU Jian-lin,WU Ji-zhou,et al.The expression and significance of Caveolin-1 and Caspase-3 protein in hepatocellular carcinoma[J].Internal Medicine of China,2012,(02):579.
[2]韦柳君,谢裕安*,任爱华,等.TSPAN8基因多态性与广西扶绥县肝癌家系遗传易感性关系研究▲[J].内科,2017,12(01):1.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2017.01.01]
 WEI Liujun,XIE Yuan,REN Aihua,et al.Relationship between the gene polymorphism of TSPAN8 and susceptibility of hepatocellular carcinoma pedigrees in Fusui County of Guangxi[J].Internal Medicine of China,2017,12(02):1.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2017.01.01]

备注/Memo

备注/Memo:
▲基金项目:国家自然科学基金资助项目(81260320)
 *通信作者:谢裕安,广西医科大学附属肿瘤医院,电子邮箱 gxxya@aliyun.com
更新日期/Last Update: 2019-05-09