[1]邱丽浈,吴共发,曾宇婷,等.MACC1在大肠癌中的表达及其与淋巴结转移的关系▲[J].内科,2019,14(02):146-150.[doi:10.16121/j.cnki.cn45-1347/r.2019.02.06]
 QIU Lizhen,WU Gongfa,ZENG Yuting,et al.Expression of MACC1 in colorectal cancer and its relationship with lymphatic metastasis[J].Internal Medicine of China,2019,14(02):146-150.[doi:10.16121/j.cnki.cn45-1347/r.2019.02.06]
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MACC1在大肠癌中的表达及其与淋巴结转移的关系▲()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
14卷
期数:
2019年02
页码:
146-150
栏目:
论著
出版日期:
2019-04-30

文章信息/Info

Title:
Expression of MACC1 in colorectal cancer and its relationship with lymphatic metastasis
文章编号:
1673-7768(2019)02-0146-05
作者:
邱丽浈1吴共发2曾宇婷2黄绮亭2刘钰君2李海刚23*
1 广州市增城区人民医院(中山大学孙逸仙纪念医院增城院区)体检中心,广州市511300;2 广州市增城区人民医院(中山大学孙逸仙纪念医院增城院区)病理科,广州市511300;3 中山大学孙逸仙纪念医院病理科,广州市510120
Author(s):
QIU Lizhen1 WU Gongfa2 ZENG Yuting2 HUANG Qiting2 LIU Yujun2 LI Haigang23
1 Physical Examination Center, Zengcheng District People′s Hospital of Guangzhou(Zengcheng District of Sun Yat-sen Memorial Hospital, Sun Yat-sen University), Guangzhou, 511300, China; 2 Department of Pathology, Zengcheng District People′s Hospital of Guangzhou(Zengcheng District of Sun Yat-sen Memorial Hospital, Sun Yat-sen University), Guangzhou, 511300, China;3 Department of Pathology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University,Guangzhou 510120, China
关键词:
大肠癌结肠癌转移相关基因-1淋巴结转移
Keywords:
Colorectal cancer Metastasis-associated in colon cancer-1 Lymph node metastasis
分类号:
R 730.3
DOI:
10.16121/j.cnki.cn45-1347/r.2019.02.06
文献标志码:
A
摘要:
目的探讨结肠癌转移相关基因-1(MACC1)在大肠癌患者癌组织、癌旁正常黏膜组织以及不同转移潜能大肠癌细胞系中的表达情况,探讨MACC1表达与大肠癌侵袭转移的关系。方法采用免疫组织化学法检测77例大肠癌患者癌组织及其癌旁正常黏膜组织中的MACC1的表达情况,分析大肠癌患者癌组织的MACC1表达与淋巴结转移、神经侵犯和临床分期等的关系;采用免疫细胞化学法检测不同转移潜能大肠癌细胞株中的MACC1的表达情况。结果大肠癌患者癌组织的MACC1阳性表达率显著高于癌旁正常黏膜组织,差异有统计学意义(P<0.05)。发生淋巴结转移的大肠癌患者其癌组织的MACC1阳性表达率(97.3%)显著高于无淋巴结转移患者(55.0%),有神经侵犯的患者其癌组织的MACC1的阳性表达率(100.0%)显著高于无神经侵犯的患者(60.4%),Ⅲ期患者其癌组织的MACC1的阳性表达率(90.0%)显著高于Ⅰ、Ⅱ期患者(60.0%,50.0%),差异均有统计学意义(P<0.05)。患者癌组织MACC1的表达与其性别、年龄、肿瘤大小、组织学分级、浸润深度无关(P>0.05)。MACC1在高侵袭转移潜能SW620细胞中的表达明显强于在低侵袭转移潜能SW480细胞中的表达(P<0.05)。结论大肠癌患者癌组织MACC1高表达,发生淋巴结转移、神经侵犯和高级别临床分期患者癌组织MACC1高表达,MACC1在高侵袭转移潜能SW620细胞中的表达较强,MACC1的表达情况与癌细胞的侵袭和转移能力密切相关。
Abstract:
ObjectiveTo investigate the expression of metastasis-associated in colon cancer-1 (MACC1) in colorectal cancer patients′ cancer tissues, adjacent normal mucosa tissues and different metastatic potential colorectal cancer cell lines, and to explore the relationship between MACC1 expression and invasion and metastasis of colorectal cancer. MethodsImmunohistochemistry was used to detect the expression of MACC1 in 77 cases of colorectal cancer and adjacent normal mucosa, the relationship between MACC1 expression and lymph node metastasis, neurological invasion and clinical stage in cancer tissues of patients with colorectal cancer was analyzed. Immunocytochemistry was used to detect the expression of MACC1 in different metastatic potential colorectal cancer cell lines. ResultsThe positive expression rate of MACC1 in cancer tissues of colorectal cancer patients was significantly higher than that in adjacent normal mucosa tissues (P<0.05). The positive expression rate of MACC1 in cancer tissues of patients with colorectal cancer with lymph node metastasis (97.3%) was significantly higher than that in patients without lymph node metastasis (55.0%). The positive expression rate of MACC1 in cancer tissues of patients with neurological invasion (100.0%) was significantly higher than that in patients without neurological invasion (60.4%). The positive expression rate of MACC1 in cancer tissues of stage III patients (90.0%) was significantly higher than that in patients with stage I and II (60.0%, 50.0%), and the difference was statistically significant (P<0.05). The expression of MACC1 in patients with cancer was not related to gender, age, tumor size, histological grade, and depth of invasion (P>0.05). The expression of MACC1 in the high invasion and metastatic potential SW620 cells was significantly stronger than that in the low invasion and metastatic potential SW480 cells (P<0.05). ConclusionThe expression of MACC1 is high in cancer tissues of patients with colorectal cancer, lymph node metastasis, neurological invasion and high-grade clinical stage, and stronger in SW620 cells with high invasion and metastatic potential, and closely related to the invasion and metastasis ability of cancer cells.

相似文献/References:

[1]陈世奇.早期大肠癌的诊治新进展[J].内科,2011,(05):491.
 [J].Internal Medicine of China,2011,(02):491.

备注/Memo

备注/Memo:
▲基金项目:广州市科技计划项目立项资助(201804010043)
 *通信作者:李海刚,广州市增城区人民医院&中山大学孙逸仙纪念医院增城院区病理科,电子邮箱 13728089120@126.com
更新日期/Last Update: 2019-05-09