[1]张兆,张千*,陆芳,等.老年急性缺血性脑梗死患者的血清NT-pro-BNP、Hcy水平及其临床意义▲[J].内科,2019,14(02):151-154.[doi:10.16121/j.cnki.cn45-1347/r.2019.02.07]
 ZHANG Zhao,ZHANG Qian,LU Fang,et al.Serum levels of NT-pro-BNP and Hcy in elderly patients with acute ischemic cerebral infarction and their clinical significance[J].Internal Medicine of China,2019,14(02):151-154.[doi:10.16121/j.cnki.cn45-1347/r.2019.02.07]
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老年急性缺血性脑梗死患者的血清NT-pro-BNP、Hcy水平及其临床意义▲()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
14卷
期数:
2019年02
页码:
151-154
栏目:
论著
出版日期:
2019-04-30

文章信息/Info

Title:
Serum levels of NT-pro-BNP and Hcy in elderly patients with acute ischemic cerebral infarction and their clinical significance
文章编号:
1673-7768(2019)02-0151-04
作者:
张兆1张千1*陆芳1汪莉2王一媚1莫瑞康1尹家喻1黄芳1冯冬梅1覃志明1钟毅1
1 广西南宁市第一人民医院(广西医科大学第五附属医院)神经内科一区,南宁市530022;2 广西南宁市第二人民医院(广西医科大学第三附属医院)护理部,南宁市530031
Author(s):
ZHANG Zhao1 ZHANG Qian1 LU Fang1 WANG Li2 WANG Yimei1 MO Ruikang1 YIN Jiayu1 HUANG Fang1 FENG Dongmei1 QIN Zhiming1 ZHONG Yi1
1 Department of Neurology, the First People′s Hospital of Nanning (the Fifth Affiliated Hospital of Guangxi Medical University), Nanning 530022, China; 2 Department of Nursing, the Second Nanning People′s Hospital (The Third Affiliated Hospital of Guangxi Medical University), Nanning 530031, China
关键词:
急性脑梗死老年N端脑钠肽前体同型半胱氨酸
Keywords:
Acute cerebral infarction Elderly N-terminal pro-brain natriuretic peptide Homocysteine
分类号:
R 543.5;R 743.32
DOI:
10.16121/j.cnki.cn45-1347/r.2019.02.07
文献标志码:
A
摘要:
目的探讨老年急性缺血性脑梗死患者的血清N端脑钠肽前体(NT-pro-BNP)、同型半胱氨酸(Hcy)水平及其临床意义。方法选取2016年2月至2017年3月在我院住院治疗的老年急性脑梗死患者56例作为观察组,根据发生脑梗死供血区域不同,将其分为前循环组(34例)与后循环组(22例);根据梗死灶直径大小,将其分为非大面积脑梗死组(33例)与大面积脑梗死组(23例);根据NIHSS评分不同,将其分为病情轻度组(50例)与病情中重度组(6例);根据出院后90 d内存活情况,将其分为死亡组(4例)与存活组(52例)。另选取同期住院治疗的非脑血管疾病患者43例作为对照组。比较观察组与对照组、前循环组与后循环组、大面积脑梗死组与非大面积脑梗死组、病情轻度组与病情中重度组、死亡组与存活组患者的血清NT-pro-BNP、Hcy水平。结果观察组患者的血清NT-pro-BNP和Hcy水平均显著高于对照组;大面积脑梗死组、病情中重度组梗死组、死亡脑梗死组患者血清NT-pro-BNP和Hcy水平均显著高于非大面积脑梗死组、病情轻度组与存活组,差异有统计学意义(P<0.05)。前循环脑梗死组患者血清NT-pro-BNP、Hcy水平与后循环组比较差异无统计学意义(P>0.05)。结论急性缺血性脑梗死患者的血清NT-pro-BNP、Hcy水平越高,其脑损害面积越大、病情越严重,短期预后越不理想。检测急性缺血性脑梗死患者血清NT-pro-BNP和Hcy水平对判断其病情的严重程度和预测其预后有重要的参考价值。
Abstract:
ObjectiveTo investigate the serum levels of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and homocysteine (Hcy) in elderly patients with acute ischemic cerebral infarction and their clinical significance. Methods56 patients with acute cerebral infarction who were admitted to our hospital from February 2016 to March 2017 were selected as the observation group. They were divided into the anterior circulation group (34 cases) and the posterior circulation group (22 cases) according to the different blood supply areas of cerebral infarction, the non-large area cerebral infarction group (33 cases) and the large area cerebral infarction group (23 cases) according to the size of the infarct size, the mild disease group (50 cases) and the moderate to severe disease group (6 cases) according to the different NIHSS scores, the death group (4 cases) and the survival group (52 cases) according to the survival within 90 days after discharge. Another 43 patients with non-cerebral vascular disease hospitalized during the same period were selected as the control group. The serum levels of NT-pro-BNP and Hcy were compared between the observation group and the control group, the anterior circulation group and the posterior circulation group, the large area cerebral infarction group and the non-large area cerebral infarction group, the mild disease group and the moderate to severe disease group, the death group and the survival group. ResultsThe serum levels of NT-pro-BNP and Hcy in the observation group were significantly higher than those in the control group. The serum levels of NT-pro-BNP and Hcy in the large-area cerebral infarction group, moderate to severe disease group and the death group were significantly higher than those in the non-large area cerebral infarction group, the mild disease group and the survival group. The difference was statistically significant (P<0.05). There were no significant differences in serum NT-pro-BNP and Hcy levels between the anterior circulation group and the posterior circulation group (P>0.05). ConclusionThe higher the serum levels of NT-pro-BNP and Hcy, the larger area of brain damage, the more serious disease, the shorter in short-term prognosis in patients with acute ischemic cerebral infarction. The detection of serum NT-pro-BNP and Hcy levels in patients with acute ischemic cerebral infarction has important reference value for judging the severity of the disease and predicting its prognosis.

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备注/Memo

备注/Memo:
▲基金项目:广西壮族自治区卫生和计划生育委员会自筹课题(Z2016137);南宁市科学研究与技术开发计划项目(重点研发计划,20173021-1 );南宁市科学研究与技术开发计划项目(20175182);南宁市科学研究与技术开发计划项目(重点研发计划,20173237);南宁市青秀区科学研究与技术开发计划项目(2013S05)
*通信作者:张千,广西南宁市第一人民医院神经内科一区,电子邮箱 zhang.doctor@163.com
更新日期/Last Update: 2019-05-09