[1]陈羽锋,陈少华,覃浩强.抗凝与双重抗血小板聚集治疗早期进展性脑梗死患者疗效比较分析[J].内科,2019,14(02):171-173+228.[doi:10.16121/j.cnki.cn45-1347/r.2019.02.13]
 Chen Yufeng,CHEN Shaohua,QIN Haoqiang.Comparative analysis of the efficacy of anticoagulation and dual antiplatelet aggregation on patients with early progressive cerebral infarction[J].Internal Medicine of China,2019,14(02):171-173+228.[doi:10.16121/j.cnki.cn45-1347/r.2019.02.13]
点击复制

抗凝与双重抗血小板聚集治疗早期进展性脑梗死患者疗效比较分析()
分享到:

《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
14卷
期数:
2019年02
页码:
171-173+228
栏目:
论著
出版日期:
2019-04-30

文章信息/Info

Title:
Comparative analysis of the efficacy of anticoagulation and dual antiplatelet aggregation on patients with early progressive cerebral infarction
文章编号:
1673-7768(2019)02-0171-04
作者:
陈羽锋陈少华覃浩强
梧州市人民医院神经内科,广西梧州市543000
Author(s):
Chen Yufeng CHEN Shaohua QIN Haoqiang
Department of Neurology, the People’s Hospital of WuZhou, Wuzhou 543000, China
关键词:
早期进展性脑梗死抗凝治疗双重抗血小板聚集
Keywords:
Early progressive cerebral infarction Anticoagulant therapy Double antiplatelet aggregation
分类号:
R 543; R 743
DOI:
10.16121/j.cnki.cn45-1347/r.2019.02.13
文献标志码:
A
摘要:
目的比较抗凝与双重抗血小板聚集治疗早期进展性脑梗死患者的临床疗效。方法选择2014年4月至2017年4月我院收治的早期进展性脑梗死患者82例,按照入院顺序随机分为抗凝组和抗血小板组。在常规治疗的基础上,抗凝组患者给予低分子肝素钙抗凝治疗,抗血小板组患者给予双重抗血小板聚集治疗。比较两组患者的NIHSS评分、治疗14 d后的mRS评分和Barthel评分;比较两组的治疗总有效率和出血性并发症的发生情况。结果两组患者在治疗前、治疗1 d、治疗7 d、治疗14 d后的NIHSS评分比较差异有统计学意义(P<0.05)。治疗7 d、14 d,抗凝组患者的治疗总有效率均显著高于抗血小板组,差异有统计学意义(P<0.05);抗凝组患者的mRS评分显著低于抗血小板组,Barthel评分显著高于抗血小板组,差异有统计学意义(P<0.05)。治疗期间,两组患者均未出现脑出血和消化道出血等出血性并发症。结论与双重抗血小板聚集治疗比较,对早期进展性脑梗死患者实施抗凝治疗效果更为显著,可更好地改善患者的神经功能缺损情况,恢复其生活能力,改善预后。
Abstract:
ObjectiveTo compare the clinical efficacy of anticoagulation and dual antiplatelet aggregation in the treatment of early progressive cerebral infarction. MethodsA total of 82 patients with early progressive cerebral infarction admitted to our hospital from April 2014 to April 2017 were randomly divided into anticoagulation group and antiplatelet group according to the order of admission. On the basis of conventional treatment, the anticoagulant group was given low molecular weight heparin calcium anticoagulant therapy and the antiplatelet group was given double antiplatelet aggregation therapy. The NIHSS score, the mRS score and Barthel score of 14 days after treatment of the two groups were compared. The total effective rate of treatment and incidence of hemorrhagic adverse complications of the two groups were compared. ResultsThere was significant difference in NIHSS scores between the two groups before treatment, 1 day, 7 days and 14 days after treatment (P<0.05).The total effective rates of anticoagulation group in 7 days and 14 days after treatment were significantly higher than those of antiplatelet group, the difference was statistically significant (P<0.05). The mRS score in the anticoagulation group was lower than that in the antiplatelet group, and Barthel score was higher than that in antiplatelet group, the difference was statistically significant (P<0.05). During the treatment period, no hemorrhagic complications such as cerebral hemorrhage and gastrointestinal bleeding occurred in the two groups. ConclusionCompared with double antiplatelet aggregation therapy, anticoagulant therapy is more effective in patients with early progressive cerebral infarction, which can better improve neurological deficits, restore their living ability and improve prognosis.

相似文献/References:

[1]郝开颜.急诊PCI术患者抗凝治疗的护理[J].内科,2011,(06):614.
 [J].Internal Medicine of China,2011,(02):614.

更新日期/Last Update: 2019-05-09