[1]张海波,张红新.头孢克肟治疗急性细菌性肠炎患者的临床效果及其对血清IL-8、PCT、TNF-α水平的影响[J].内科,2019,14(02):177-179.[doi:10.16121/j.cnki.cn45-1347/r.2019.02.15]
 ZHANG Haibo,ZHANG Hongxin.Clinical efficacy of cefixime in patients with acute bacterial enteritis and its effect on serum IL-8, PCT and TNF-α levels[J].Internal Medicine of China,2019,14(02):177-179.[doi:10.16121/j.cnki.cn45-1347/r.2019.02.15]
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头孢克肟治疗急性细菌性肠炎患者的临床效果及其对血清IL-8、PCT、TNF-α水平的影响()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
14卷
期数:
2019年02
页码:
177-179
栏目:
论著
出版日期:
2019-04-30

文章信息/Info

Title:
Clinical efficacy of cefixime in patients with acute bacterial enteritis and its effect on serum IL-8, PCT and TNF-α levels
文章编号:
1673-7768(2019)02-0177-03
作者:
张海波张红新
南阳市西峡县人民医院消化内科,河南省南阳市474550
Author(s):
ZHANG Haibo ZHANG Hongxin
Department of Digestive, Xixia County People′s Hospital, Nanyang 474550, China
关键词:
急性细菌性肠炎头孢克洛头孢克肟炎症因子
Keywords:
Acute bacterial enteritis Cefixime Cefaclor Inflammatory factor
分类号:
R 516.1
DOI:
10.16121/j.cnki.cn45-1347/r.2019.02.15
文献标志码:
A
摘要:
目的探讨头孢克肟治疗急性细菌性肠炎患者的临床效果及其对血清白介素-8(IL-8)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)水平的影响。方法选取2017年4月至2018年7月在我院治疗的急性细菌性肠炎患者96例作为研究对象,随机分为观察组与对照组,每组48例。两组患者均进行常规治疗。在此基础上,对照组患者口服头孢克洛治疗,观察组患者口服头孢克肟治疗。两组患者均连续治疗7 d。比较两组患者的临床疗效以及腹泻情况;检测比较治疗前后两组患者的血清IL-8、PCT、TNF-α水平。结果治疗7 d后,观察组患者的治疗总有效率(97.92%)显著高于对照组(72.92%),腹泻次数显著少于对照组,血清IL-8、PCT以及TNF-α水平显著低于对照组,差异均有统计学意义(P<0.05)。结论在常规治疗的基础上,应用头孢克肟治疗急性细菌性肠炎患者临床疗效确切,可有效改善患者腹泻症状,同时降低患者血清炎症因子水平。
Abstract:
ObjectiveTo explore the clinical efficacy of cefixime in patients with acute bacterial enteritis and its effect on serum Interleukin-8(IL-8), procalcitonin(PCT)and tumor necrosis factor-α(TNF-α)levels. Methods96 patients with acute bacterial enteritis who were admitted to our hospital from April 2017 to July 2018 were selected as the research objects and randomly divided into observation group and control group, with 48 cases in each group. On the basis of conventional treatment, the observation group was treated with cefixime and control group was treated with cefaclor. Both groups were treated for 7 days. The clinical effects and diarrhea were compared between the two groups. The serum IL-8, PCT and TNF-α levels before and after treatment in the two groups were detected and compared. ResultsAfter 7 days of treatment, the total effective rate of observation group (97.92%) was significantly higher than that of the control group (72.92%), the diarrhea frequency was significantly less than that in the control group and the levels of serum IL-8, PCT and TNF-α were significantly lower than those in the control group, the difference was statistically significant (P<0.05). ConclusionOn the basis of conventional treatment, cefixime is definite in clinical efficacy in treating patients with acute bacterial enteritis, which can effectively improve the symptoms of diarrhea and reduce the level of serum inflammatory factors.
更新日期/Last Update: 2019-05-09