[1]莫小云,吴林秀*,刘春斌,等.2型糖尿病患者发生轻度认知障碍相关因素分析▲[J].内科,2019,14(04):392-396.[doi:10.16121/j.cnki.cn45-1347/r.2019.04.03]
 MO Xiaoyun,WU Linxiu*,LIU Chunbin,et al.Analysis of related factors of mild cognitive impairment in patients with type 2 diabetes mellitus[J].Internal Medicine of China,2019,14(04):392-396.[doi:10.16121/j.cnki.cn45-1347/r.2019.04.03]
点击复制

2型糖尿病患者发生轻度认知障碍相关因素分析▲()
分享到:

《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
14卷
期数:
2019年04
页码:
392-396
栏目:
论著
出版日期:
2019-08-29

文章信息/Info

Title:
Analysis of related factors of mild cognitive impairment in patients with type 2 diabetes mellitus
文章编号:
1673-7768(2019)04-0392-05
作者:
莫小云1吴林秀1*刘春斌2覃小双3张丽娣1吴潇芸1何华梅1黄文婷1
1 广西卫生职业技术学院,南宁市530023;2 广西南宁市第一人民医院,南宁市530022;3 广西壮族自治区人民医院,南宁市530001
Author(s):
MO Xiaoyun1 WU Linxiu1* LIU Chunbin2 QIN Xiaoshuang3 ZHANG Lidi1 WU Xiaoyun1 HE Huamei1 HUANG Wenting1
1 Guangxi Medical College, Nanning 530021,China; 2 The First People′s Hospital of Nanning, Nanning 530021,China; 3 The People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530001)
关键词:
2型糖尿病轻度认知功能障碍影响因素阿尔茨海默病
Keywords:
Type 2 diabetes mellitus Mild cognitive impairment Influencing factors Alzheimer’s disease
分类号:
R 587
DOI:
10.16121/j.cnki.cn45-1347/r.2019.04.03
文献标志码:
A
摘要:
目的探讨2型糖尿病(T2DM)患者发生轻度认知障碍(MCI)的相关因素,为预防T2DM患者认知功能减退甚至向痴呆转变提供科学依据。方法采用蒙特利尔认知量表(MoCA)对212例T2DM患者认知功能进行测定,根据MoCA评分将患者分为MCI组(MoCA评分≤26分,74例)和非MCI组(MoCA评分>26分,138例),对影响T2DM患者发生MCI的危险因素进行单因素和多因素Logistic回归分析,对T2DM患者MCI发病影响因素与MoCA评分的关系进行Pearson相关分析。结果T2MD患者的MCI患病率为34.9%。单因素分析发现,MCI和非MCI患者的年龄、受教育程度、血红蛋白水平、空腹血葡萄糖水平、服用二甲双胍年限、糖尿病病程、糖化血红蛋白(HbA1c)水平、血清C-肽(空腹、餐后0.5 h、餐后1h、餐后2h)水平和高密度脂蛋白胆固醇水平比较,差异均有统计学意义(P<0.05);多因素Logistic回归分析发现,高龄、糖尿病病程长、HbA1c水平高、服用二甲双胍年限短、受教育程度低是T2DM患者发生MCI的独立危险因素。Pearson相关分析结果显示,T2DM患者的年龄、糖尿病病程、HbA1c水平与MoCA评分呈负相关(P<0.05);服用二甲双胍年限、受教育程度与MoCA评分呈正相关(P<0.05)。结论高龄、糖尿病病程长、HbA1c水平高是T2DM患者发生MCI的危险因素,服用二甲双胍年限长、受教育程度高是保护因素。早期对T2DM患者进行认知功能评价,针对患者发生MCI的影响因素及时进行有效干预,对预防、延缓阿尔茨海默病的发生具有重要意义。
Abstract:
ObjectiveTo explore the related factors of mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus (T2DM), so as to provide a scientific basis for preventing cognitive decline or even occurring transition to dementia in patients with T2DM. MethodsThe cognitive function of 212 patients with T2DM was measured by the Montreal Cognitive Assessment (MoCA). Patients were divided into MCI group (MoCA score ≤26, 74 cases) and non-MCI group (MoCA score>26, 138 cases) in accordance with MoCA scores. Univariate analysis and multivariate logistic regression analysis were performed on risk factors for MCI in patients with T2DM. Pearson correlation analysis was performed on the relationship between the effective factors of MCI pathogenesis and MoCA scores in T2DM patients. ResultsThe prevalence rate of MCI in T2MD patients was 34.9%. Univariate analysis revealed that age, educational qualification, hemoglobin level, fasting blood glucose level, duration of taking metformin, duration of diabetes, hemoglobin A1c (HbA1c) level, serum C-peptide (fasting, 0.5 h postprandial, 1h postprandial, 2h postprandial) level, and high-density lipoprotein cholesterol level in the MCI and non-MCI group, was statistically significantly different (P<0.05), whereas multivariate logistic regression analysis showed that advanced age, long duration of diabetes, high HbA1c level, short duration of taking metformin, and low educational qualification were independent risk factors for MCI in T2DM patients. Pearson correlation analysis revealed that age, duration of diabetes, and HbA1c level were negatively correlated with MoCA scores in T2DM patients (P<0.05), while there was a positive correlation between the duration of taking metformin, educational qualification and MoCA scores (P<0.05). ConclusionAdvanced age, long duration of diabetes, and high HbA1c level are risk factors for MCI in patients with T2DM. The long duration of taking metformin and the high level of educational qualification are protective factors. It is of great significance to prevent and delay the occurrence of Alzheimer′s disease through early evaluating the cognitive function in patients with T2DM, and timely and effectively intervening influencing factors of MCI in T2DM patients.

相似文献/References:

[1]江燕 梁瑜祯*.2型糖尿病患者血清铁蛋白与血脂、体重指数等相关性分析[J].内科,2015,(03):288.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.03.02]
 JIANG Yan,LIANG Yu-zhen.Correlation with serum ferritin and serum lipids, BMI and other factors in patients with type 2 diabetes mellitus[J].Internal Medicine of China,2015,(04):288.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.03.02]
[2]谭庆华 王建华 张建仪.诺和锐30不同注射次数对2型糖尿病合并肺结核患者血糖的影响[J].内科,2015,(03):320.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.03.14]
 [J].Internal Medicine of China,2015,(04):320.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.03.14]
[3]李廷尉.2型糖尿病患者合并周围神经病变相关危险因素分析[J].内科,2015,(03):339.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.03.23]
 [J].Internal Medicine of China,2015,(04):339.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.03.23]
[4]刘凌霞 成景山 韦昭华 潘新华 莫芳梅.2型糖尿病患者并发糖尿病足的相关危险因素分析[J].内科,2015,(04):498.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.04.24]
 [J].Internal Medicine of China,2015,(04):498.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.04.24]
[5]梁志金.2型糖尿病患者自我管理研究进展[J].内科,2015,(04):541.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.04.43]
 [J].Internal Medicine of China,2015,(04):541.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.04.43]
[6]卢梅英.综合护理干预提高2型糖尿病患者自我管理能力的效果分析[J].内科,2015,(04):589.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.04.61]
 [J].Internal Medicine of China,2015,(04):589.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.04.61]
[7]夏俊卿.吡格列酮治疗2型糖尿病并发心血管疾病的疗效观察[J].内科,2014,(01):32.
 [J].Internal Medicine of China,2014,(04):32.
[8]阮传青.品管圈活动在2型糖尿病健康教育中的应用效果观察[J].内科,2014,(03):302.
[9]蒋婵 夏碧文 刘雪芳 曾炼坤.甘精胰岛素联合赖脯胰岛素强化治疗2型糖尿病临床疗效和安全性观察[J].内科,2014,(06):656.
 JIANG Chan,XIA Bi-wen,LIU Xue-fang,et al.Effectiveness and safety of the intensive therapy of insulin glargine combined with insulin lispro for patients with type 2 diabetes[J].Internal Medicine of China,2014,(04):656.
[10]李超炎.二甲双胍、格列美脲、阿卡波糖治疗2型糖尿病的临床疗效观察[J].内科,2014,(06):679.
 [J].Internal Medicine of China,2014,(04):679.

备注/Memo

备注/Memo:
▲基金项目:2014年度广西高校科学技术研究项目(YB2014543);2015年度广西高校科学技术研究项目(KY2015YB460);广西卫生职业技术学院2014年度校本科研项目(WZ2014ZA03)
*通信作者:吴林秀,广西卫生职业技术学院,电子邮箱 78875722@qq.com
更新日期/Last Update: 2019-08-30