[1]李燕青,郭春连,卢家淇.甲氨蝶呤联合雷公藤多苷片治疗类风湿性关节炎患者的疗效及不良反应分析[J].内科,2019,14(04):424-426.[doi:10.16121/j.cnki.cn45-1347/r.2019.04.12]
 LI Yanqing,GUO Chunlian,LU Jiaqi.Analysis of the efficacy and adverse reactions of methotrexate combined with tripterygium glycosides tablet on rheumatoid arthritis[J].Internal Medicine of China,2019,14(04):424-426.[doi:10.16121/j.cnki.cn45-1347/r.2019.04.12]
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甲氨蝶呤联合雷公藤多苷片治疗类风湿性关节炎患者的疗效及不良反应分析()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
14卷
期数:
2019年04
页码:
424-426
栏目:
论著
出版日期:
2019-08-29

文章信息/Info

Title:
Analysis of the efficacy and adverse reactions of methotrexate combined with tripterygium glycosides tablet on rheumatoid arthritis
文章编号:
1673-7768(2019)04-0424-03
作者:
李燕青郭春连卢家淇
惠州市第一人民医院药学部,广东省惠州市516000
Author(s):
LI Yanqing GUO Chunlian LU Jiaqi
Department of Pharmacy, Huizhou first people′s hospital, Huizhou 516000, Guangdong province, China
关键词:
类风湿性关节炎甲氨蝶呤雷公藤多苷片不良反应
Keywords:
Rheumatoid arthritis Methotrexate Tripterygium glycosides tablet Adverse reactions
分类号:
R 593
DOI:
10.16121/j.cnki.cn45-1347/r.2019.04.12
文献标志码:
A
摘要:
目的探讨甲氨蝶呤联合雷公藤多苷片治疗类风湿性关节炎的疗效及不良反应情况。方法选取2016年1月至2018年6月我院收治的类风湿性关节炎患者130例,根据患者治疗意愿分为甲氨蝶呤组(63例)和联合治疗组(67例)。甲氨蝶呤组采用甲氨蝶呤治疗,联合治疗组采用甲氨蝶呤+雷公藤多苷片治疗,比较两组患者的临床治疗效果、红细胞沉降率(ESR)、C反应蛋白(CRP)水平和不良反应发生情况。结果治疗3个疗程后,两组患者的疼痛程度、关节压痛个数、关节肿胀个数、晨僵时间均明显降低(减少),ESR、CRP水平明显降低,联合治疗组患者上述指标水平均显著优于甲氨蝶呤组,差异有统计学意义(P<0.05)。治疗过程中,两组患者的不良反应发生率相比较,差异无统计学意义(P>0.05)。结论甲氨蝶呤联合雷公藤多苷片治疗类风湿性关节炎患者临床效果显著,可有效改善患者的临床症状,降低炎症反应水平,治疗安全性较高,值得推广应用。
Abstract:
ObjectiveTo explore the efficacy and adverse reactions of methotrexate combined with tripterygium glycosides tablet on rheumatoid arthritis. MethodsA total of 130 patients with rheumatoid arthritis admitted in our hospital from January 2016 to June 2018 were selected as the study objects, and divided into methotrexate group (63 cases) and combined treatment group (67 cases) according to the patient′s will of treatment. The methotrexate group was treated with methotrexate, whereas the combined treatment group was treated with methotrexate combined with tripterygium glycosides tablet. The clinical efficacy, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels and adverse reactions were compared between the two groups. ResultsAfter 3 courses of treatment, the pain level, the number of joint tenderness, the number of joint swelling, and the morning stiffness time were significantly decreased (reduced), and the ESR and CRP levels were significantly decreased. The above mentioned indicators of the combined treatment group were significantly better than the methotrexate group, with statistically significant difference (P<0.05). During treatment, there was no statistically significant difference in the incidence rate of adverse reactions in the two groups (P>0.05). ConclusionMethotrexate combined with tripterygium glycosides tablet in the treatment of rheumatoid arthritis patients revealed a prominent clinical effect, which can effectively improve the clinical symptoms, and reduce the level of inflammatory response. It has high safety of treatment, which is worthy of promotion and application.

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更新日期/Last Update: 2019-08-30