[1]张耀源,陈荣健.纤支镜肺泡灌洗治疗对急性重症肺炎合并呼吸衰竭患者血气分析及血清学指标的影响[J].内科,2019,14(05):554-556.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2019.05.14]
 ZHANG Yaoyuan,CHEN Rongjian.Effect of fiber bronchoscopic alveolar lavage on blood gas analysis and serological indicators in patients with severe pneumonia and comorbid respiratory failure[J].Internal Medicine of China,2019,14(05):554-556.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2019.05.14]
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纤支镜肺泡灌洗治疗对急性重症肺炎合并呼吸衰竭患者血气分析及血清学指标的影响()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
14卷
期数:
2019年05
页码:
554-556
栏目:
论著
出版日期:
2019-10-31

文章信息/Info

Title:
Effect of fiber bronchoscopic alveolar lavage on blood gas analysis and serological indicators in patients with severe pneumonia and comorbid respiratory failure
文章编号:
1673-7768(2019)05-0554-03
作者:
张耀源陈荣健
江门市中心医院急诊科,广东省江门市529000
Author(s):
ZHANG Yaoyuan CHEN Rongjian
Department of Emergency, Jiangmen Central Hospital, Jiangmen 529000, Guangdong province, China
关键词:
急性重症肺炎呼吸衰竭纤支镜肺泡灌洗血气分析血清学
Keywords:
Acute severe pneumonia Respiratory failure Fiber bronchoscopic alveolar lavage Blood gas analysis Serology
分类号:
R 562
DOI:
DOI:10.16121/j.cnki.cn45-1347/r.2019.05.14
文献标志码:
A
摘要:
目的探究纤支镜肺泡灌洗治疗对急性重症肺炎合并呼吸衰竭患者血气分析及血清学指标的影响。方法选取2016年3月至2018年2月我院急诊科收治的急性重症肺炎合并呼吸衰竭患者60例作为研究对象。对所有患者进行数字编号,根据单双号将患者分为对照组和观察组,每组30例。对照组患者给予常规治疗,观察组患者给予常规治疗+纤支镜肺泡灌洗治疗。检测比较两组患者治疗前和治疗第3天的动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、氧合指数(PaO2/FiO2)、CD11B阳性中性粒细胞比例、高迁移率族蛋白B1(HMGB-1)水平及可溶性髓系细胞触发受体-1(sTREM-1)水平。结果治疗前,两组患者的PaO2、PaCO2、PaO2/FiO2、CD11B阳性中性粒细胞比例、sTREM-1水平、HMGB-1水平相比较,差异无统计学意义(P>0.05)。治疗第3天,观察组患者的PaO2、PaO2/FiO2显著高于对照组,PaCO2、CD11B阳性中性粒细胞比例、sTREM-1水平、HMGB-1水平均显著低于对照组,差异有统计学意义(P<0.05)。结论纤支镜肺泡灌洗治疗可有效改善急性重症肺炎合并呼吸衰竭患者的血气分析及血清学指标水平,值得推广应用。
Abstract:
ObjectiveTo investigate the effect of fiber bronchoscopic alveolar lavage on blood gas analysis and serological indexes in patients with acute severe pneumonia and comorbid respiratory failure. MethodsA total of 60 patients with acute severe pneumonia and comorbid respiratory failure admitted to the department of emergency of our hospital from March 2016 to February 2018 were selected as the objects. All patients were numbered, and divided into control group and observation group according to single and double numbers, with 30 cases in each group. The control group was treated with conventional treatment, and the observation group was treated with conventional treatment plus fiber bronchoscopic alveolar lavage. The partial arterial oxygen pressure (PaO2), the partial pressure of carbon dioxide in arterial blood (PaCO2), oxygenation index (PaO2/FiO2), CD11B positive neutrophil ratio, high-mobility group box-1 (HMGB-1), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) levels were detected and compared between the two groups before treatment and on the third day of treatment. ResultsBefore treatment, there were no statistically significant differences in PaO2, PaCO2, PaO2/FiO2, CD11B positive neutrophil ratio, sTREM-1 level and HMGB-1 level between the two groups (P>0.05). On the third day of treatment, PaO2 and PaO2/FiO2 were significantly higher in the observation group than in the control group, whereas PaCO2, CD11B positive neutrophil ratio, sTREM-1 and HMGB-1 levels were significantly lower than those of the control group, with statistically significant difference (P<0.05). ConclusionPatients with acute severe pneumonia and comorbid respiratory failure treated with fiber bronchoscopic alveolar lavage can effectively improve blood gas analysis and serological indicators, and it is worthy of clinical promotion and application.

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更新日期/Last Update: 2019-11-04