[1]杨云,朱永杰.肺炎支原体肺炎重症患儿的临床特点、病情影响因素及其与儿科危重病例评分的关系分析▲[J].内科,2020,15(01):11-13.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2020.01.04]
 YANG Yun,ZHU Yongjie.Analysis on relationship between clinical characteristics, disease influencing factors and pediatric critical illness score in children with severe mycoplasma pneumoniae pneumonia[J].Internal Medicine of China,2020,15(01):11-13.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2020.01.04]
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肺炎支原体肺炎重症患儿的临床特点、病情影响因素及其与儿科危重病例评分的关系分析▲()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
15卷
期数:
2020年01
页码:
11-13
栏目:
论著
出版日期:
2020-03-31

文章信息/Info

Title:
Analysis on relationship between clinical characteristics, disease influencing factors and pediatric critical illness score in children with severe mycoplasma pneumoniae pneumonia
文章编号:
1673-7768(2020)01-0011-03
作者:
杨云1朱永杰2
1 固始县人民医院,河南省信阳市465200;2 郑州市儿童医院,河南省信阳市450053
Author(s):
YANG Yun1 ZHU Yongjie2
1 People’s Hospital of Gushi County, Xinyang 465200, Henan Province, China; 2 Zhengzhou Children’s Hospital, Xinyang 450053, Henan Province, China
关键词:
支原体肺部感染重症肺炎临床特点病情影响因素危重病例评分
Keywords:
Mycoplasma pulmonary infection Severe pneumonia Clinical characteristic Influencing factor of disease Pediatric critical illness score
分类号:
R 563
DOI:
DOI:10.16121/j.cnki.cn45-1347/r.2020.01.04
文献标志码:
A
摘要:
目的探讨肺炎支原体肺炎(MPP)重症患儿的临床特点、病情影响因素及其与儿科危重病例评分(PCIS)的关系。方法选取2016年1月至2018年12月我院收治的支原体肺部感染肺炎患儿116例为研究对象。根据PCIS将患儿分为非危重组(>80分),危重组(70~80 分)以及极危重组(<70分),比较三组患儿的性别、年龄、实验室检查指标、合并感染情况、心电图表现等;对影响患儿病情严重程度的危险因素进行多因素Logistic回归分析;对PCIS评分与患儿D-二聚体水平、合并2种及以上病原感染、前白蛋白(PA)水平的关系进行 Spearman相关分析。结果三组患儿合并2种及以上病原感染、病程>12 d、合并2个及以上系统损害、D-二聚体水平、谷丙转氨酶水平、PA水平比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,合并2种及以上病原感染、病程>12 d、D-二聚体水平异常、谷丙转氨酶水平异常及PA水平下降是导致MPP患儿病情危重的危险因素。Spearman相关分析结果显示,PCIS评分与MPP患儿D-二聚体水平、合并2种及以上病原感染呈正相关(r=0.352,P<0.05;r=0.384,P<0.05),与PA水平呈负相关(r=-0.319,P<0.05)。结论肺炎支原体肺炎重症患儿常合并2种及以上的病原体感染;患儿前白蛋白、D-二聚体水平与PCIS评分密切相关,可作为判定患儿病情严重程度的重要指标。
Abstract:
ObjectiveTo investigate the relationship between clinical characteristics, disease influencing factors and pediatric critical illness score (PCIS) in children with severe mycoplasma pneumoniae pneumonia(MPP). MethodsA total of 116 children with severe MPP admitted to our hospital from January 2016 to December 2018 were selected as the research subjects and divided into non-critical group (>80 points), critical group (70-80 points), and extremely critical group (<70 points) according to PCIS. The gender, age, laboratory test indicators, co-infection condition, electrocardiography manifestation etc. were compared between the three groups. Multivariate logistic regression analysis was used to identify risk factors affecting the severity of disease. Spearman correlation analysis was performed on the relationship between the PCIS and D-dimer level, co-infected with two or more pathogens, and prealbumin (PA) level. ResultsThere were statistically significant differences in co-infected with two or more pathogens, disease course>12 d, complicated with two or more systematic damages, D-dimer level, alanine aminotransferase level, and PA level between the three groups (P<0.05). Multivariate logistic regression analysis results showed that patients co-infected with two or more pathogens, disease course>12 days, abnormal D-dimer and alanine aminotransferase levels, as well as decreased PA level were the risk factors for critical children with severe MPP. Spearman correlation analysis results showed that the PCIS was positively correlated with D-dimer level and co-infected with two or more pathogens in children with MPP (r=0.352, P<0.05; r=0.384, P<0.05), whereas the PCIS was negatively correlated with PA level (r=-0.319, P<0.05). ConclusionChildren with severe MPP often co-infect with two or more pathogens, PA and D-dimer levels were closely correlated with PCIS, and thus these crucial indicators can be used to determine the disease severity.

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备注/Memo

备注/Memo:
▲基金项目:2014年度河南省医学科技攻关计划项目(201403258)
更新日期/Last Update: 2020-04-07