[1]覃显波,黄晓雅,林金环.H型高血压患者肾损害危险因素的多因素Logistic回归分析[J].内科,2020,15(01):39-41+44.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2020.01.13]
 QIN Xianbo,HUANG Xiaoya,LIN Jinhuan.Multivariate logistic regression analysis of risk factors for Renal Damage in patients with H-type hypertension[J].Internal Medicine of China,2020,15(01):39-41+44.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2020.01.13]
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H型高血压患者肾损害危险因素的多因素Logistic回归分析()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
15卷
期数:
2020年01
页码:
39-41+44
栏目:
论著
出版日期:
2020-03-31

文章信息/Info

Title:
Multivariate logistic regression analysis of risk factors for Renal Damage in patients with H-type hypertension
文章编号:
1673-7768(2020)01-0039-04
作者:
覃显波黄晓雅林金环
梧州市中医医院内四科,广西梧州市543000
Author(s):
QIN Xianbo HUANG Xiaoya LIN Jinhuan
The Forth Department of Internal Medicine, Wuzhou Traditional Chinese Medicine Hospital, Wuzhou 543000, Guangxi, China
关键词:
H型高血压肾损害危险因素回归分析
Keywords:
H-type hypertension Renal damage Risk factor Regression analysis
分类号:
R 544.1
DOI:
DOI:10.16121/j.cnki.cn45-1347/r.2020.01.13
文献标志码:
A
摘要:
目的探讨H型高血压患者肾损害的危险因素,为有效预防患者出现肾损害提供参考。方法回顾性分析2016年1月至2017年1月在我院诊治的186例H型高血压患者的临床资料,根据患者肾小球滤过率(GFR)将患者分为正常组(GFR≥90 mL/L,共148例)和损伤组(GFR<90 mL/L,共38例)。对两组患者的性别、年龄、病程、收缩压、视黄醇结合蛋白、血同型半胱氨酸(Hcy)、胱抑素C(Cys-C)、β2微球蛋白(β2-MG)、血肌酐、尿酸等进行比较分析,对导致H型高血压患者发生肾损害的因素进行多因素Logistic回归分析。结果单因素分析结果显示,H型高血压损伤组患者的Hcy、Cys-C、β2-MG表达水平均显著高于正常组,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,Hcy>20.13 μmol/L、Cys-C>1.83 mg/L、β2-MG>3.12 mg/L是H型高血压患者发生肾损害的独立危险因素(P<0.05)。结论Hcy、Cys-C、β2-MG水平升高与H型高血压患者的肾损害密切相关,对患者进行检测,及早采取针对性干预措施,可能有助于预防肾损伤,改善预后。
Abstract:
ObjectiveTo explore the risk factors for renal damage in patients with H-type hypertension, so as to provide a reference of effective prevention for patients occurring renal damage. MethodsThe clinical data of 186 patients with H-type hypertension diagnosed and treated in our hospital from January 2016 to January 2017 were retrospectively analyzed and divided into normal group (GFR≥90mL/L, 148 patients in total) and injury group (GFR<90 mL/L, 38 patients in total) according to the glomerular filtration rate (GFR). Gender, age, course of disease, systolic blood pressure, retinol binding protein, homocysteine (Hcy), Cystatin C (Cys-C), β2 microglobulin (β2-MG), serum creatinine, and uric acid etc. were compared and analyzed between the two groups. Multivariate logistic regression analysis was performed to analysed the factors for renal damage in patients with H-type hypertension. ResultsUnivariate analysis results showed that Patients with H-type hypertension in the injury group obtained significantly higher expression levels of Hcy, Cys-C, β2-MG compared to the normal group, with statistically significant differences (P<0.05). Multivariate logistic regression analysis results showed that Hcy>20.13 μmol/L, Cys-C>1.83 mg/L, β2-MG>3.12 mg/L were independent risk factors for renal damage in patients with H-type hypertension (P<0.05) . ConclusionElevated levels of Hcy, Cys-C, and β2-MG are closely related to renal damage in patients with H-type hypertension. Early detection and targeted intervention may be conducive to preventing renal damage, and improving prognosis.

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更新日期/Last Update: 2020-04-07