[1]黄国仪,何清,廖雪姣,等.HBV/HCV重叠感染患者HBV DNA、HCV RNA的复制及肝脏损害情况分析▲[J].内科,2020,15(03):249-252.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2020.03.01]
 HUANG Guoyi,HE Qing,LIAO Xuejiao,et al.Analysis of HBV DNA and HCV RNA replication and liver damage in patients with HBV/HCV superinfection[J].Internal Medicine of China,2020,15(03):249-252.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2020.03.01]
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HBV/HCV重叠感染患者HBV DNA、HCV RNA的复制及肝脏损害情况分析▲()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
15卷
期数:
2020年03
页码:
249-252
栏目:
论著
出版日期:
2020-07-03

文章信息/Info

Title:
Analysis of HBV DNA and HCV RNA replication and liver damage in patients with HBV/HCV superinfection
文章编号:
1673-7768(2020)03-0249-04
作者:
黄国仪何清廖雪姣李雅唐奇远赖长祥
深圳市第三人民医院,广东省深圳市518112
Author(s):
HUANG Guoyi HE Qing LIAO Xuejiao LI Ya TANG Qiyuan LAI Changxiang
The Third People′s Hospital of Shenzhen, Shenzhen 518112, Guangdong province, China
关键词:
丙型肝炎病毒乙型肝炎病毒重叠感染病毒复制肝脏损害
Keywords:
Hepatitis C virus Hepatitis B virus Superinfection Virus replication Liver damage
分类号:
R 575.1
DOI:
DOI:10.16121/j.cnki.cn45-1347/r.2020.03.01
文献标志码:
A
摘要:
目的探讨HBV/HCV重叠感染患者HBV DNA、HCV RNA的复制及肝脏损害情况,加深对HBV/HCV重叠感染患者的认识。方法选取2000~2013年在深圳市第三人民医院住院治疗的HBV/HCV重叠感染患者116例为研究对象。根据患者HBV DNA、HCV RNA实时荧光定量PCR定量检测结果,将患者分为4组,即HBV单阳性组(27例)、HCV单阳性组(49例)、双阳性组(17例)和双阴性组(23例)。比较4组患者年龄、性别、可能传播途径的差异;检测比较4组患者的谷丙转氨酶(ALT)水平及肝纤维化情况;对双阳性组患者的HBV DNA水平与其HCV RNA水平的关系进行Pearson相关性分析;比较4组患者的HBV DNA及HCV RNA复制水平。结果双阴性组患者的年龄显著小于其他3组患者,差异有统计学意义(P<0.05);4组患者的ALT水平表现为HBV单阳性组>双阴性组>双阳性组>HCV单阳性组,差异有统计学意义(P<0.05),中重度肝纤维化表现为HBV单阳性组(25.9%)>双阳性组(23.5%)>HCV单阳性组(18.4%)>双阴性组(17.4%),但差异无统计学意义(P>0.05)。Pearson相关性分析结果显示,双阳性组患者的HBV DNA水平与其HCV RNA水平呈负相关(r=-0.519)。双阳性组患者的HBV DNA复制水平明显低于HBV单阳性组,差异有统计学意义(P<0.05)。结论HBV/HCV重叠感染患者体内HBV DNA与HCV RNA复制存在相互抑制和消耗情况,重叠感染患者体内HCV RNA复制占主导地位可能会促使其HBV自发阴性率有所增高。
Abstract:
ObjectiveTo explore the replication of HBV DNA and HCV RNA, and liver damage in patients with HBV/HCV superinfection, to deepen the understanding of patients with HBV/HCV superinfection. MethodsA total of 116 patients with HBV/HCV superinfection hospitalized in the Third People′s Hospital of Shenzhen from 2000 to 2013 were selected as the research objects. According to the real-time fluorescence quantitative PCR detection results of HBV DNA and HCV RNA, patients were divided into 4 groups, namely HBV single positive group (27 cases), HCV single positive group (49 cases), double-positive group (17 cases) and double negative group (23 cases). Age, gender, and differences in possible transmission routes of the 4 groups were compared. The alanine aminotransferase (ALT) level and liver fibrosis of the 4 groups were detected and compared. Pearson correlation analysis was used to analyze the relationship between levels of HBV DNA and HCV RNA in the double-positive group. HBV DNA and HCV RNA replication levels of the 4 groups were compared. ResultsPatients in the double negative group were significantly younger than those in the other three groups, with a statistically significant difference (P<0.05). Descending order was presented in the ALT level following HBV single positive group, double negative group, double-positive group, and HCV single positive group, with a statistically significant difference (P<0.05) as well as moderate-severe liver fibrosis as follows: HBV single positive group (25.9%), double-positive group (23.5%), HCV single positive group (18.4%), and double negative group (17.4%), without a statistically significant difference (P>0.05). Pearson correlation analysis showed that the HBV DNA level was negatively correlated with its HCV RNA level in the double-positive group (r=-0.519). The HBV DNA replication level of patients in the double-positive group was significantly lower than that in the HBV single positive group, with a statistically significant difference (P<0.05). ConclusionHBV DNA and HCV RNA replication showed mutual interactions and depletion in patients with HBV/HCV superinfection. HCV RNA replication plays a predominant role in superinfection patients, which may increase HBV spontaneous negative rate.

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备注/Memo

备注/Memo:
▲基金项目:深圳市“医疗卫生三名工程”王福生院士团队(SZSM201612014)通信作者:何清,广东医科大学附属深圳市第三人民医院,电子邮箱 heqingjoe@163.com
更新日期/Last Update: 2020-07-07