[1]尹浡,杜鹏,夏开.喜格迈治疗对急性非ST段抬高心肌梗死PCI术后患者心功能及血清CK-MB、MYO、cTnI、BNP、H-FABP水平的影响▲[J].内科,2020,15(03):268-271.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2020.03.06]
 YIN Bo,Du Peng,XIA Kai.Effect of sigmart on cardiac function and serum CK-MB, MYO, cTnI, BNP, H-FABP levels in patients with acute non-ST-segment elevation myocardial infarction after PCI[J].Internal Medicine of China,2020,15(03):268-271.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2020.03.06]
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喜格迈治疗对急性非ST段抬高心肌梗死PCI术后患者心功能及血清CK-MB、MYO、cTnI、BNP、H-FABP水平的影响▲()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
15卷
期数:
2020年03
页码:
268-271
栏目:
论著
出版日期:
2020-07-03

文章信息/Info

Title:
Effect of sigmart on cardiac function and serum CK-MB, MYO, cTnI, BNP, H-FABP levels in patients with acute non-ST-segment elevation myocardial infarction after PCI
文章编号:
1673-7768(2020)03-0268-04
作者:
尹浡杜鹏夏开
郑州市第七人民医院,河南省郑州市450000
Author(s):
YIN Bo Du Peng XIA Kai
The 7th People′s Hospital of Zhengzhou, Zhengzhou 450000, Henan province, China
关键词:
急性心肌梗死非ST段抬高型经皮冠状动脉介入术喜格迈
Keywords:
Acute myocardial infarction Non-ST-segment elevation Percutaneous coronary intervention Sigmart
分类号:
R 543.3
DOI:
DOI:10.16121/j.cnki.cn45-1347/r.2020.03.06
文献标志码:
A
摘要:
目的探讨喜格迈治疗对急性非ST段抬高心肌梗死(NSTEMI)经皮冠状动脉介入(PCI)术后患者的心功能及血清心肌标志物水平的影响。方法选择2017年8月至2019年1月在我院行PCI术治疗的NSTEMI患者110例为研究对象,采用随机数字法分为观察组和对照组,每组55例。对照组患者PCI术后给予常规后续药物治疗,观察组患者在对照组治疗的基础上加服喜格迈治疗,疗程4周。比较两组患者治疗前后的血清肌酸激酶同工酶(CK-MB)、肌红蛋白(MYO)、血清肌钙蛋白I(cTnI)、脑利尿钠肽(BNP)、心肌脂肪酸结合蛋白(H-FABP)水平;比较两组患者的左室射血分数(LVEF)、左室收缩末内径(LVESD)、左室舒张末内径(LVEDD);疗程结束后随访6个月,比较两组患者的心脏不良事件发生情况。结果治疗前,两组患者的血清CK-MB、MYO、cTnI、BNP、H-FABP水平比较,差异无统计学意义(P>0.05);治疗4周后,对照组患者的血清CK-MB、MYO、cTnI水平显著升高,BNP、H-FABP水平显著降低, CK-MB、MYO、cTnI、BNP、H-FABP水平均显著高于观察组,差异有统计学意义(P<0.05)。治疗前,两组患者的LVEF、LVESD及LVEDD水平比较,差异无统计学意义(P>0.05)。治疗4周后,两组患者的LVEF水平均显著升高,观察组患者的水平显著高于对照组;两组患者的LVESD、LVEDD水平均显著降低,观察组患者的水平显著低于对照组,差异有统计学意义(P<0.05)。疗程结束后随访6个月,观察组患者的心脏不良事件发生率显著低于对照组,差异有统计学意义(P<0.05)。结论喜格迈可减轻急性非ST段抬高心肌梗死 PCI术后患者的心肌缺血再灌注损伤,改善心功能,减少心脏不良事件发生,值得临床推广使用。
Abstract:
ObjectiveTo investigate the effect of sigmart on cardiac function and serum myocardial marker levels in patients with acute non-ST-segment elevation myocardial infarction (NSTEMI) after the percutaneous coronary intervention (PCI). MethodsA total of 110 patients with NSTEMI who underwent PCI surgery in our hospital from August 2017 to January 2019 were selected as the research objects. The patients were divided into observation group and control group by the random number method, with 55 cases in each group. The control group was given conventional follow-up drug treatment after PCI, whereas the observation group was additionally administered sigmart based on the therapy in the control group, for a four-week treatment course. The pre- and post-treatment serum creatine kinase isoenzyme (CK-MB), myoglobin (MYO), serum cardiac troponin I (cTnI), brain natriuretic peptide (BNP), and heart-type fatty acid-binding protein (H-FABP) levels, as well as left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), and the occurrence of adverse cardiac events six-month follow-up after the end of treatment courses were compared between the two groups. ResultsBefore treatment, there were no statistically significant differences in serum CK-MB, MYO, cTnI, BNP, H-FABP levels between the two groups (P>0.05). After 4 weeks of treatment, the serum CK-MB, MYO, cTnI levels of the control group increased significantly, whereas BNP, H-FABP levels decreased significantly. The control group yielded higher CK-MB, MYO, cTnI BNP, H-FABP levels as compared with the observation group, with statistically significant differences (P<0.05). Before treatment, there were no statistically significant differences in the levels of LVEF, LVESD, and LVEDD between the two groups (P>0.05). After 4 weeks of treatment, the LVEF level in both groups increased significantly, whereas LVESD and LVEDD levels decreased prominently. The observation group yielded a higher LVEF level and lower LVESD and LVEDD levels as compared to the control group, with statistically significant differences (P<0.05). Six-month follow-up after the end of treatment courses, the incidence of adverse cardiac events in the observation group was significantly lower than that in the control group, with statistically significant differences (P<0.05). ConclusionSigmart can reduce myocardial ischemia-reperfusion injury in patients with NSTEMI after PCI, improve cardiac function, and reduce the occurrence of adverse cardiac events, which is worthy of clinical promotion.

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备注/Memo

备注/Memo:
▲基金项目:河南省科技攻关计划项目(2018020861)
更新日期/Last Update: 2020-07-07