[1]刘雅胜,郑志坚,马天斌,等.宫颈癌术后患者静态调强放疗及旋转容积调强放疗效果对比分析▲[J].内科,2020,15(03):289-292.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2020.03.12]
 LIU Yasheng,ZHENG Zhijian,MA Tianbin,et al.Effect of static intensity-modulated radiotherapy and volumetric modulated arc therapy for postoperative cervical cancer patients: a comparative analysis[J].Internal Medicine of China,2020,15(03):289-292.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2020.03.12]
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宫颈癌术后患者静态调强放疗及旋转容积调强放疗效果对比分析▲()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
15卷
期数:
2020年03
页码:
289-292
栏目:
论著
出版日期:
2020-07-03

文章信息/Info

Title:
Effect of static intensity-modulated radiotherapy and volumetric modulated arc therapy for postoperative cervical cancer patients: a comparative analysis
文章编号:
1673-7768(2020)03-0289-04
作者:
刘雅胜1郑志坚1马天斌2罗金锋1
梅州市人民医院(1 盆腔放疗科,2 放射治疗科),广东省梅州市514000
Author(s):
LIU Yasheng1 ZHENG Zhijian1 MA Tianbin2 LUO Jinfeng1
Meizhou People′s Hospital (1 Department of Pelvic Radiotherapy, 2 Department of Radiotherapy), Meizhou 514000, Guangdong Province, China
关键词:
子宫颈癌静态调强放疗旋转容积调强放疗不良反应
Keywords:
Cervical cancer Static intensity-modulated radiotherapy Volumetric modulated arc therapy Adverse reaction
分类号:
R 572;R 815
DOI:
DOI:10.16121/j.cnki.cn45-1347/r.2020.03.12
文献标志码:
A
摘要:
目的对比分析静态调强放疗(IMRT)及旋转容积调强放疗(VMAT)治疗子宫颈癌术后患者的临床效果及对患者的不良影响。方法选取2016年1月至2018年8月我院收治的子宫颈癌术后需行放疗的患者 100例为研究对象,根据患者意愿和治疗需要分为对照组(60例)和观察组(40例)。对照组患者接受IMRT治疗,观察组患者接受VMAT治疗。比较两组患者危及器官的受照剂量;比较两组患者的急性毒副作用出现情况及1年生存情况。结果观察组患者的直肠、小肠V40显著小于对照组,差异有统计学意义(P<0.05);直肠、小肠V20、V30及膀胱V20、V30、V40与对照组比较,差异均无统计学意义(P>0.05)。观察组患者的消化道反应、泌尿系统反应及骨髓抑制的严重程度均显著轻于对照组,差异有统计学意义(P<0.05)。观察组患者的1年生存率显著高于对照组,差异有统计学意义(P<0.05)。结论在宫颈癌根治术后放射治疗中,与采用IMRT技术比较VMAT技术能更有效地保护危及器官,减轻患者放疗相关急性毒副作用,提高患者的1年生存率。
Abstract:
ObjectiveTo compare and analyze the clinical and adverse effects of static intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) in the treatment of postoperative cervical cancer patients. MethodsA total of 100 patients with cervical cancer who needed radiotherapy after the operation in our hospital from January 2016 to August 2018 were selected as the research objects, and they were divided into control group (60 cases) and observation group (40 cases) according to their wills and treatment requires. Patients in the control group received IMRT, and the observation group received VMAT. The exposure doses of organ at risk, the occurrence of acute toxic side effects, and one-year survival status were compared between the two groups. ResultsThe V40 of the rectum and small intestine in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P<0.05). There were no statistically significant differences in the V20 and V30 of the rectum and small intestine, and V20,V30 and V40 of the bladder of the observation group as compared with the control group (P>0.05). As compared with the control group, the observation group yielded a lower severity of digestive tract, urinary system reaction and bone marrow, whereas a higher one-year survival rate, with statistically significant differences (P<0.05). ConclusionEmploying the VMAT technique is more effective to protect organs at risk, alleviate relative acute toxic side effects of radiotherapy, and increase the one-year survival rate of patients as compared with the IMRT technique in radiotherapy after radical hysterectomy.

备注/Memo

备注/Memo:
▲基金项目:梅州市科技计划项目(2018B031)
更新日期/Last Update: 2020-07-07