[1]董春红.2型糖尿病患者的甲状腺功能与其血脂代谢、糖尿病肾病发病的关系[J].内科,2020,15(03):297-299.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2020.03.14]
 DONG Chunhong.Relationship between thyroid function, blood lipid metabolism and the onset of diabetic nephropathy in patients with type 2 diabetes[J].Internal Medicine of China,2020,15(03):297-299.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2020.03.14]
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2型糖尿病患者的甲状腺功能与其血脂代谢、糖尿病肾病发病的关系()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
15卷
期数:
2020年03
页码:
297-299
栏目:
论著
出版日期:
2020-07-03

文章信息/Info

Title:
Relationship between thyroid function, blood lipid metabolism and the onset of diabetic nephropathy in patients with type 2 diabetes
文章编号:
1673-7768(2020)03-0297-03
作者:
董春红
洛阳市中医院,河南省洛阳市471000
Author(s):
DONG Chunhong
Luoyang Hospital of TCM, Luoyang 471000, Henan Province, China
关键词:
2型糖尿病甲状腺功能血脂糖尿病肾病
Keywords:
Type 2 diabetes Thyroid function Blood lipid Diabetic nephropathy
分类号:
R 581;R 587.1
DOI:
DOI:10.16121/j.cnki.cn45-1347/r.2020.03.14
文献标志码:
A
摘要:
目的探讨2型糖尿病患者的甲状腺功能与其血脂代谢及糖尿病肾病发病的关系。方法选取2015年8月至2017年8月在本院就诊的2型糖尿病患者106例为研究对象,检测患者血清中游离甲状腺素、游离三碘甲状腺原氨酸及促甲状腺激素水平,根据检测结果将患者分为甲状腺功能减退组(24例)和甲状腺功能正常组(82例)。检测比较两组患者的一般情况、血脂水平、肾功能、糖尿病肾病发病情况。结果甲状腺功能减退组患者的女性比例、抗甲状腺过氧化酶抗体水平显著高于甲状腺功能正常组患者,差异有统计学意义(P<0.05)。甲状腺功能减退组患者的总胆固醇、三酰甘油、低密度脂蛋白水平均显著高于甲状腺功能正常组,差异有统计学意义(P<0.05)。甲状腺功能减退组患者的肾小球滤过率显著低于甲状腺功能正常组,尿液微量白蛋白含量显著高于甲状腺功能正常组,差异有统计学意义(P<0.05)。甲状腺功能减退组患者的糖尿病肾病发病率(25.0%)显著高于甲状腺功能正常组(8.5%),差异有统计学意义(P<0.05)。结论甲状腺功能减退会导致2型糖尿病患者血脂代谢异常、糖尿病肾病发病率增高;对2型糖尿病患者的甲状腺功能进行监测干预,可能有助于降低患者的糖尿病肾病发生率。
Abstract:
ObjectiveTo investigate the relationship between thyroid function, blood lipid metabolism, and the onset of diabetic nephropathy in patients with type 2 diabetes. MethodsA total of 106 patients with type 2 diabetes treated in our hospital from August 2015 to August 2017 were selected as the research objects. The serum levels of free thyroxine, free triiodothyronine, and thyroid-stimulating hormone were detected in patients. Patients were divided into hypothyroidism group (24 cases) and normal thyroid function group (82 cases) according to the test results. The general status, blood lipid level, renal function, and onset of diabetic nephropathy were compared between the two groups. ResultsPatients in the hypothyroidism group obtained higher proportion of women and levels of antithyroid peroxidase antibody, total cholesterol, triacylglycerol, and low-density lipoprotein, whereas a lower glomerular filtration rate, but higher urine microalbumin content and morbidity of diabetic nephropathy (25% vs. 8.5%), as compared with those indicators in the normal thyroid function group, with statistically significant differences (P<0.05). ConclusionHypothyroidism can lead to abnormal blood lipid metabolism and increase morbidity of diabetic nephropathy in patients with type 2 diabetes. Monitoring and intervening thyroid function in patients with type 2 diabetes may help to decrease the morbidity of diabetes nephropathy.

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更新日期/Last Update: 2020-07-07