目的探讨植物性雌激素配合米非司酮治疗子宫肌瘤（UL）合并缺铁性贫血（IDA）的效果。方法选取UL合并IDA患者70例，按随机数字表法分为研究组和对照组，每组35例。在纠正贫血治疗的基础上，对照组患者采用米非司酮治疗，研究组患者采用植物性雌激素配合米非司酮治疗，观察对比两组患者治疗前后血红蛋白、UL体积、血清性激素、一氧化氮合酶（NOS）、肿瘤坏死因子-α（TNF-α）水平等的变化情况。结果治疗后，两组患者血红蛋白量显著升高、UL体积显著缩小（P＜0.01），研究组患者血红蛋白量显著高于对照组、UL体积显著小于对照组（P＜0.01）；两组患者血清性激素水平显著下降（P＜0.01）；研究组患者血清性激素水平明显低于对照组（P＜0.05或0.01）；两组患者血清NOS、TNF-α水平显著下降（P＜0.01）；研究组患者血清NOS、TNF-α水平显著低于对照组（P＜0.05或0.01）。两组患者不良反应发生率比较差异无统计学意义（P＞0.05）。结论采用植物性雌激素配合米非司酮治疗UL合并IDA患者疗效显著，可有效缩小UL体积，改善患者血清激素、NOS及TNF-α水平，安全可靠，值得在临床推广使用。

ObjectiveTo investigate the efficacy of phytoestrogens combined with mifepristone in the treatment of patients with uterine leiomyoma (UL) complicated with iron deficiency anemia (IDA). MethodsA total of 70 patients with UL complicated with IDA were randomly divided into study group and control group, with 35 cases in each group. Both the two groups were given the treatment of anemia, on the basis of anemia-correction, the control group was treated with mifepristone, while the study group was treated with mifepristone combined with phytoestrogens.The levels of hemoglobin,UL volume, serum sex hormones, nitric oxide synthase (NOS), tumor necrosis factor-α(TNF-α) were compared between two groups before and after treatment. ResultsThe levels of hemoglobin increased significantly while the UL volume decreased significantly in two groups after treatment in contrast with those before treatment (P＜0.01) , and the levels of hemoglobin in the study group was significantly higher than that in the control group (P＜0.05), and the UL volume was significantly less than that in the control group (P＜0.05); after treatment, the levels of serum sex hormones, NOS and TNF-α in the two groups significantly decreased compared with those before treatment(P＜0.05), and the decreased in the study group was more significant (P＜0.05 or P＜0.05).No significant difference of adverse reaction was found between the two groups (P＞0.05). ConclusionsPhytoestrogens combined with mifepristone in the treatment of patients with UL complicated with IDA has significant curative effect ,and can effectively reduce the UL volume, improve the levels of serum hormone,NOS and TNF-α, which is safety and worthy of promotion and application in clinical.

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