【Abstract】ObjectiveTo analyze the HIV prevalence and AIDSrelated risk factors among 945 lowgrade female sex workers in Laibin city, thereby to provide decisionmaking for making intervention measures. MethodsQuestionnaire was usesd to investigate 945 lowgrade female sex workers in Laibin city, the demographic data, information of AIDS knowledge, sexual behavior were gathered, and HIV antibody was tested. ResultsThe average age of the respondents was (38.2±7.6)years old, the educational level of the subjects major in primary school and below (89.2%); the rate of condom use during the last sexual intercourse was 93.2%, the rate of consistent condom use during commercial sex behavior was 88.4% in recent one month; the HIV antibody positive rate was 2.6%; the logistic regression analysis showed that the frequency of condom use in recent one month was the protective factor for HIV infection. ConclusionsOlder, low educational level, low rate of condom use, low awareness of AIDS are the characteristics of lowgrade female sex workers in Laibin city, the popularization of AIDS knowledge need to be strengthened among lowgrade female sex workers to improve their safety awareness.