ObjectiveTo investigate the effect of superselected intraaterial thrombolysis on elderly patients with acute cerebral infarction in intracervical artery system, the efficiency and safety of intra-arterial thrombolysis therapy within 3 to 6 hours and intravenous thrombolysis therapy within 3 hours after onset of acute cerebral infarction were evaluated. MethodsThe clinical data of 33 elderly patients with acute cerebral infarction who onset within 6 hours were retrospectively analyzed, 18 patients were treated with intra-arterial thrombolysis using urokinase(onset within3-6 h, intraaterial thrombolysis group) ,15 patients were treated with intravenous thrombolysis using urokinase(onset within 6h, venous thrombolysis group). The NIHSS score of two groups were evaluated before and after thrombolysis 3h、24h、14 d,the Barthel Index (BI) of two groups were evaluated before and after thrombolysis 7 d、90d, and adverse reactions were also observed in both groups. ResultsThe NIHSS score at 3h, 24h, 14 d and the Barthel Index at 7 d, 90d improved significantly after treatment, there was significant difference before and after thrombolysis(P＜0.05).There was no significant difference in NIHSS score and Barthel Index between the two groups at each time point, and the incidence of adverse reactions in two groups had no statistically significant(P＞0.05). ConclusionsThe intra-arterial thrombolysis have the same efficacy in short-term effect and long-term prognosis as intravenous thrombolysis after acute cerebral infarction.