[1]赵茂林 卫训 罗素红.厄贝沙坦联合阿托伐他汀治疗原发性高血压80例临床研究[J].内科,2012,(01):5-6.
 ZHAO Mao-lin,WEI Xun,LUO Su-hong.Clinical research of erbesartan combined with atorvastatin in the treatment of 80 patients with primary hypertension[J].Internal Medicine of China,2012,(01):5-6.
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厄贝沙坦联合阿托伐他汀治疗原发性高血压80例临床研究()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2012年01期
页码:
5-6
栏目:
论著
出版日期:
2012-02-25

文章信息/Info

Title:
Clinical research of erbesartan combined with atorvastatin in the treatment of 80 patients with primary hypertension
文章编号:
1673-7768(2012)01-0005-02
作者:
赵茂林 卫训 罗素红
英山县人民医院内科,湖北省英山县438700
Author(s):
ZHAO Mao-linWEI XunLUO Su-hong
Department of internal medicine,people′s hospital of Yingshan county,Yingshan,Hubei 438700 China
关键词:
原发性高血压治疗厄贝沙坦阿托伐他汀
Keywords:
Primary hypertensionTreatErbesartanAtorvastatin
分类号:
R 544.1
文献标志码:
B
摘要:
目的探讨联合应用降压药物厄贝沙坦和调脂药物阿托代他汀治疗原发性高血压的临床疗效。方法将160例原发性高血压患者随机分成对照组和观察组各80例。对照组单纯给予厄贝沙坦或加用硝苯地平缓释片治疗,观察组在此基础上加用阿托伐他汀片治疗。6个月后对比分析两组的动态血压、血脂、血尿酸。结果两组患者血压均得到有效控制,治疗6个月后两组24 h平均收缩压(24hSBp)及24 h平均舒张压(24hDBp)差异无统计学意义(P>0.05);观察组24 h平均压(24hpp)及血脂水平均低于对照组(P<0.05)。结论联合应用降压药物厄贝沙坦和调脂药物阿托代他汀治疗原发性高血压能有效降低患者24 h平均压及血尿酸,从而更有效地保护靶器官。
Abstract:
ObjectiveTo explore the clinical efficacy of erbesartan combined with atorvastatin in the treatment of primary hypertension.Methods160 patients with primary hypertension were randomly divided into control group and observation group,80 cases in each group.The control group was given erbesartan or nifedipine sustained-release tablets in addition,while the observation group was given atorvastatin on the basic therapy of control group.After 6 months of treatment,ambulatory blood pressure,serum lipids,blood uric acid were analyzed and compared.ResultsAfter 6 months of treatment,the blood pressure were control effectively.Before and after treatment the patient blood pressure was controlled effectively.There were no significant difference between 24hSPp and 24hDBp of the two groups above(P>0.05).24hpp and blood liquid level of the observation group were significantly lower than that of the control group(P<0.05).ConclusionIt′s helpful using erbesartan combined with atorvastatin to decrease 24hpp and blood uric acid of patients with primary hypertension, so as to protect the target organ of hypertension effectively.

参考文献/References:

[1]陆再英,钟南山.内科学[M].第7版.北京:人民卫生出版社,2008:251.
[2]中国高血压防治指南修订委员会.2004年中国高血压防治指南[J].高血压杂志,2004,12(6):483-486.
[3]White WB.Relevance of boold pressure variation in the circadian ouset of cardiovasular events[J].J Hypertension Suppl,2003,21(6):S9-15.
[4]崔凤燕,董华.高血压及冠心病患者的尿酸水平观察(附286例分析)[J].福建医药杂志,2003,25(1):57-58.
[5]陈正贵,孙健,马立坚.高血压患者动态脉压与左心室肥厚的相关性研究[J].中国医师进修杂志·内科版,2006,29(5):17-19.
[6]张静,曲鹏.老年原发性高血压患者脉压与血尿酸相关性分析及辛伐他汀对其影响[J].中国医师进修杂志·综合版,2010,23(10):9-12.
[7]徐盛开,伏静媛,宁金民,等.阿托伐他汀对高血压患者血管内皮功能的影响[J].高血压杂志,2005,13(7):403-406.

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更新日期/Last Update: 2015-12-07