[1]蔡继强 容经伟 曾伟光 曾艳芳.血清胱抑素C对原发性高血压早期肾功能损害的诊断价值[J].内科,2015,(04):439-441.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.04.02]
 CAI Ji-qiang,RONG Jing-wei,ZENG Wei-guang,et al.Clinical application of serum cystatin C in early renal function injury patients caused by hypertension[J].Internal Medicine of China,2015,(04):439-441.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.04.02]
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血清胱抑素C对原发性高血压早期肾功能损害的诊断价值()
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《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2015年04期
页码:
439-441
栏目:
论著
出版日期:
2015-08-15

文章信息/Info

Title:
Clinical application of serum cystatin C in early renal function injury patients caused by hypertension
文章编号:
1673-7768(2015)04-0439-03
作者:
蔡继强1 容经伟1 曾伟光2 曾艳芳3
1广东省珠海市斗门区井岸镇卫生院,珠海市519100;2遵义医学院附属(珠海)第五医院医保科,珠海市519100;3珠海市人民医院门诊部,珠海市519000
Author(s):
CAI Ji-qiang1 RONG Jing-wei1 ZENG Wei-guang2 ZENG Yan-fang3
1Zhuhai doumen district Jing,an town health centers in guangdong province, Zhuhai, 519100,China; 2Department of Medical Insurance,The Fifth Affiliated Hospital of Zunyi Medical College (Zhuhai), Zhuhai 519100,China; 3Department of outpatient, the People’s Hospital of Zhuhai, Zhuhai 519000, China
关键词:
血清胱抑C原发性高血压肾功能损害
Keywords:
Serum Cys-C Essential hypertension Renal impairment
分类号:
R 544.1;R 692
DOI:
DOI:10.16121/j.cnki.cn45-1347/r.2015.04.02
文献标志码:
B
摘要:
目的探讨血清胱抑素C(Cys C)在原发性高血压早期肾功能损害诊断中的作用。方法选取原发性高血压患者186例作为观察对象,按高血压程度分为高血压Ⅰ级组、高血压Ⅱ级组、高血压Ⅲ级组,每组62例。检测患者肾小球滤过率(GFR)和Cys C,分析GFR、Cys C浓度与原发性高血压程度的关系。结果不同血压水平的三组患者的GFR值差异有统计学意义(P<0.05),Ⅰ级组>Ⅱ级组>Ⅲ级组;三组患者的血清Cys C浓度差异有统计学意义(P<0.05),Ⅲ级组>Ⅱ级组>Ⅰ级组;三组患者的血清肌酐、尿素氮、尿酸差异无统计学意义(P>0.05)。相关分析结果显示,患者血压水平与GFR值呈负相关(r=-0.491),与Cys C浓度呈正相关(r=0.835)。结论Cys C的浓度测定方法简便、迅速、灵敏,可作为临床诊断、预测原发性高血压早期肾功能损害的指标,值得临床推广应用。
Abstract:
ObjectiveTo analyze the clinical effect of serum cystatin C(Cys C) in early renal function injury patients caused by hypertension. Methods186 patients with essential hypertension were divided into hypertension gradeⅠgroup, hypertension grade Ⅱgroup, hypertension gradeⅢ group according to the degree of high blood pressure,62 cases in each group. The level of GFR and Cys C were detected, and the correlation analysis between GFR, Cys C and the degree of essential hypertension was carried out. ResultsThe value of GFR in hypertension gradeⅠgroup was higher than that in hypertension grade Ⅱgroup,and the hypertension gradeⅢ group was the least, the difference between the three groups was statistically significant(P<0.05); the level of serum Cys-C had statistical significance in three groups (P<0.05), and the level of serum Cys-C increase with the renal function impairmen; there was no significant difference in detecting rate of the serum creatinine, urea nitrogen, uric acid in three groups(P>0.05) .The correlation analysis results show that the level of blood pressure was negatively correlated to GFR(r=-0.491) but positive correlated with serum Cys-C(r=0.835). ConclusionsThe detection of serum Cys C is simple, rapid and sensitive, it can be an index for diagnosis and predicting of renal dysfunction in patients with hypertension,which is worth to populate and apply.

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2015-05-04修回日期:2015-06-30)
更新日期/Last Update: 2015-10-09