[1]葛恒文,胡新俊.泮托拉唑钠联合奥曲肽治疗肝硬化上消化道出血患者的临床效果及对炎症反应的影响▲[J].内科,2020,15(06):641-643.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2020.06.02]
 GE Hengwen,HU Xinjun.Clinical effect of pantoprazole sodium combined with octreotide in the treatment of patients with liver cirrhosis upper gastrointestinal bleeding and its influence on inflammatory response[J].Internal Medicine of China,2020,15(06):641-643.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2020.06.02]
点击复制

泮托拉唑钠联合奥曲肽治疗肝硬化上消化道出血患者的临床效果及对炎症反应的影响▲()
分享到:

《内科》[ISSN:1006-6977/CN:61-1281/TN]

卷:
15卷
期数:
2020年06
页码:
641-643
栏目:
论著
出版日期:
2020-12-31

文章信息/Info

Title:
Clinical effect of pantoprazole sodium combined with octreotide in the treatment of patients with liver cirrhosis upper gastrointestinal bleeding and its influence on inflammatory response
文章编号:
1673-7768(2020)06-0641-03
作者:
葛恒文胡新俊
新蔡县人民医院消化内科,河南省驻马店市463500
Author(s):
GE Hengwen HU Xinjun
Department of Gastroenterology, Xincai County People′s Hospital, Zhumadian 463500, Henan Province, China
关键词:
肝硬化上消化道出血泮托拉唑钠奥曲肽止血效果炎症指标
Keywords:
Liver cirrhosis Upper gastrointestinal bleeding Octreotide Pantoprazole sodium Hemostatic effect Inflammatory index
分类号:
R 573.2
DOI:
DOI:10.16121/j.cnki.cn45-1347/r.2020.06.02
文献标志码:
A
摘要:
目的探究泮托拉唑钠联合奥曲肽治疗肝硬化上消化道出血患者的临床效果及对患者炎症指标水平的影响。方法选取2018年10月至2020年1月我院收治的肝硬化上消化道出血患者135例为研究对象,根据治疗方案不同分为对照组(66例)和观察组(69例)。两组患者均进行常规禁食、禁水、补充血容量、维持电解质平衡等治疗以及抗病毒治疗。在此基础上,对照组患者加用泮托拉唑钠治疗,观察组患者加用泮托拉唑钠+醋酸奥曲肽注射液治疗,疗程3天。比较两组患者的临床疗效、治疗前后的血清炎症指标水平及不良反应发生情况。结果观察组患者的治疗总有效率(95.7%)显著高于对照组(83.3%),差异有统计学意义(P<0.05)。治疗前,两组患者的IL-1β、TNF-α、PCT水平比较,差异无统计学意义(P>0.05);治疗3 d后,两组患者的IL-1β、TNF-α、PCT水平均显著降低,观察组患者的水平显著低于对照组,差异有统计学意义(P<0.05)。观察组患者的不良反应发生率(10.6%)略低于对照组(11.6%),但差异无统计学意义(P<0.05)。结论泮托拉唑钠联合奥曲肽治疗肝硬化上消化道出血患者临床疗效显著,能显著缓解机体炎症反应,但不会增加不良反应的发生。
Abstract:
ObjectiveTo explore the clinical effect of pantoprazole sodium combined with octreotide in the treatment of patients with liver cirrhosis upper gastrointestinal bleeding, and its influence on inflammatory indexes levels of patients. MethodsA total of 135 patients with liver cirrhosis upper gastrointestinal bleeding admitted to our hospital from October 2018 to January 2020 were selected as the research objects. According to the different treatment options, they were divided into control group (66 cases) and observation group (69 cases). Both groups of patients were given conventional treatments, including fasting, water-depriving, blood volume supplementation, electrolyte balance maintenance, and antiviral treatment, based on which patients in the control group were additionally treated with pantoprazole sodium, whereas patients in the observation group were additionally treated with pantoprazole sodium + octreotide acetate injection, for a three-day treatment course. The clinical efficacy, serum inflammatory indexes levels before and after treatment, and the occurrence of adverse reactions were compared between the two groups. ResultsThe total effective rate of treatment in the observation group (95.7%) was significantly higher than that in the control group (83.3%), and the difference was statistically significant (P<0.05). There were no statistically significant differences in the levels of IL-1β, TNF-α, and PCT between the two groups before treatment(P>0.05). After 3 days of treatment, the levels of IL-1β, TNF-α, and PCT of the two groups significantly decreased, and the levels mentioned above in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P<0.05). The incidence of adverse reactions in the observation group (10.6%) was slightly lower than that in the control group (11.6%), but the difference was not statistically significant. ConclusionPantoprazole sodium combined with octreotide has a significant clinical effect in the treatment of patients with liver cirrhosis upper gastrointestinal bleeding, which can significantly alleviate the inflammatory response of the body, but it will not increase the occurrence of adverse reactions.

相似文献/References:

[1]郑丽梅 杨波 陈仕梅.内镜治疗心血管术后上消化道出血33例临床观察[J].内科,2015,(02):188.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.02.18]
[2]方进琳.急性酒精中毒并发上消化道出血45例诊治体会[J].内科,2015,(02):235.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.02.40]
 [J].Internal Medicine of China,2015,(06):235.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.02.40]
[3]蓝常明.肝硬化合并肝源性糖尿病49例临床分析[J].内科,2014,(06):700.
 [J].Internal Medicine of China,2014,(06):700.
[4]童锡宝.肝硬化腹水伴自发性细菌性腹膜炎90例临床分析[J].内科,2015,(05):672.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.05.27]
 [J].Internal Medicine of China,2015,(06):672.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.05.27]
[5]练满娇.临床护理路径在病毒性肝炎肝硬化合并消化道出血患者中的应用效果分析[J].内科,2015,(05):699.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.05.38]
 [J].Internal Medicine of China,2015,(06):699.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.05.38]
[6]李迎春.心理护理干预对肝硬化急性上消化道出血患者疗效的影响[J].内科,2015,(05):737.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.05.56]
 [J].Internal Medicine of China,2015,(06):737.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.05.56]
[7]苏东星 吴县斌 庞丽兴.门冬氨酸鸟氨酸治疗肝硬化伴发肝性脑病68例疗效观察[J].内科,2013,(04):362.
 [J].Internal Medicine of China,2013,(06):362.
[8]陆文权.兰索拉唑治疗上消化道内出血临床观察[J].内科,2013,(04):372.
[9]梁剑.侗族青年上消化道出血116例的临床特点与治疗效果观察[J].内科,2013,(04):389.
 [J].Internal Medicine of China,2013,(06):389.
[10]范俊华 唐国都 姜海行 黄杰安 彭志刚.肝硬化脾功能亢进症误诊为特发性血小板减少症1例[J].内科,2013,(06):652.
 [J].Internal Medicine of China,2013,(06):652.
[11]覃永旗彭云波.醋酸奥曲肽联合盐酸普萘洛尔治疗肝硬化门静脉高压致上消化道出血患者40例的临床效果[J].内科,2015,(01):22.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2015.01.09]
[12]邹杏坚,郭宏兴.专科护理在肝硬化合并上消化道出血患者治疗中的应用效果分析▲[J].内科,2019,14(05):615.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2019.05.35]
 [J].Internal Medicine of China,2019,14(06):615.[doi:DOI:10.16121/j.cnki.cn45-1347/r.2019.05.35]

备注/Memo

备注/Memo:
▲基金项目:国家自然科学基金项目(81600512)
更新日期/Last Update: 2021-01-11