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当前位置：首页 / 不同剂量阿托伐他汀对急性脑梗死患者高敏C反应蛋白、白细胞介素6、肿瘤坏死因子α的影响

论著 | 更新时间：2015-12-07

不同剂量阿托伐他汀对急性脑梗死患者高敏C反应蛋白、白细胞介素6、肿瘤坏死因子α的影响

Influences of different doses of Atorvastatin on the serum levels of hs-CRP、IL-6 and TNF-α in acute cerebral infarction patients

刘迪　张武昌　张雄　罗汝琴

内科 201201期页码：3-4

作者机构：武汉市武昌医院，湖北省武汉市430063

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目的探讨不同剂量阿托伐他汀对急性脑梗死患者高敏C反应蛋白（hs-CRP）、白细胞介素6（IL-6）及肿瘤坏死因子α（TNF-α）水平的影响。方法选择84例急性脑梗死患者分为两组（A组和B组），在常规治疗的基础上，A组口服阿托伐他汀10 mg/d，B组采用口服阿托伐他汀20 mg/d，两组均治疗4周，观察两组患者用药前后hs-CRP、IL-6及TNF-α的变化。结果阿托伐他汀可降低急性脑梗死患者血清hs-CRP、IL-6及TNF-a水平，并呈量效关系。结论大剂量应用阿托伐他汀可明显减轻急性脑梗死炎性反应。

ObjectiveTo explore the influences of different doses of Atorvastatin on the serum levels of hs-CRP、IL-6 and TNF-α in acute cerebral infarction patients(ACI).Methods84 patients with ACI were recruited and randomly divided into two groups(group A and group B).On the basic of conventional treatment,patients of group A took atorvastatin orally,10 mg/d,while patients of group B took 20 mg/d,both for four weeks.The serum Levels of hs-CRP、IL-6 and TNF-α were detected before and after 4 weeks of treatment.ResultsThe serum Levels of hs-CRP、IL-6 and TNF-α decreased after four weeks of treatment with atorvastatin,and a dose-response relationship were shown.ConclusionsUsage of high-dose atorvastatin may significantly reduce the inflammatory response in ACI patients.

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