内科

目的探讨系统性红斑狼疮（SLE）患者血清基质金属蛋白酶9（MMP-9）及其抑制物（TIMP-1）的表达特点及临床意义。方法用双抗体夹心酶联免疫吸附试验（ELISA）检测64例SLE患者（SLE组）和25名健康人（对照组）血清MMP-9和TIMP-1的水平并进行比较分析。结果SLE组患者血清MMP-9水平明显低于对照组，TIMP-1明显高于对照组（P＜0.01），且MMP-9/TIMP-1低于对照组（P＜0.05）；SLE患者活动期血清MMP-9、MMP-9/TIMP-1明显低于缓解期（P＜0.05），但TIMP-1的水平差异无统计学意义（P＞0.05）；狼疮肾炎组MMP-9低于非肾炎组（P＜0.05），但TIMP-1差异无统计学意义（P＞0.05）；MMP-9及TIMP-1水平在LN各病理类型患者中的差异无统计学意义（P＞0.05）；患者的临床表现与MMP-9及TIMP-1水平无明显关系。结论MMP-9及TIMP-1可能参与SLE的发病，血清MMP-9水平可作为反映SLE活动程度、肾脏损害的指标。

ObjectiveTo explore the characteristic of express of serum matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinases-1(TIMP-1）in patients with systemic lupus erythematosus(SLE) and investigate its clinical significance.MethodsThe levels of serum MMP-9 and TIMP-1 of 64 patients with SLE(SLE group) and 25 healthy(control group) were measured by ELISA.ResultsThe levels of serum MMP-9 of SLE patients were significantly lower than that of the control group,but the TIMP-1 was higher than control group(P＜0.01);and the ratio of MMP-9 to TIMP-1 in SLE patients was lower than healthy control group(P＜0.05).In active SLE patients,the levels of serum MMP-9 and the ratio of MMP-9 to TIMP-1 were lower than inactive SLE patients;but there was no significant differences of serum TIMP-1 between active SLE patients and inactive SLE patients.The lupus nephritis(LN) patients′serum MMP-9 level was lower than the SLE patients without LN,but there was no significant differences of serum TIMP-1 level between the lupus nephritis patients and the SLE patients without LN(P＞0.05).The MMP-9 and TIMP-1 serum levels were no significant differences between different pathological categories.There were no significant relationship between MMP-9,TIMP-1 and clinical manifestations.ConclusionMMP-9 and TIMP-1 may be involved in the pathogenesis of SLE,and the level of serum MMP-9 may be used as an indicator to monitor disease activity,renal damage.