ObjectiveTo investigate the role that CD4+ CD25+regulatory T cells play in the immune mechanism of type 2 diabetic patients with angiopathy.MethodsCD4+ CD25+、CD4+、CD8+ of 18 patients with type 2 diabetic combined with angiopathy,20 patients of type 2 diabetic without angiopathy and 25 cases of healthy were measured by flow cytometry,and the ratio of CD4+CD25+/CD4+ were caculated.The results were compared between the three groups.ResultsThe CD4+ CD25+regulatory T cells counts and the ratio of CD4+CD25+/CD4+ of type 2 diabetic patients with angiopathy were higher than health people(P＜0.05),the CD4+ CD25+ regulatory T cells counts of type 2 diabetic patients without angiopathy group is lower than type 2 diabetic patients with angiopathy group(P＜0.05).ConclusionThe CD4+ CD25+regulatory T cells counts and the ratio of CD4+CD25+/CD4+ in type 2 diabetic patients with angiopathy are higher than health people, may concerned with their inflammatory reactions.

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