ObjectiveTo investigate the effect of compound Lactobacillus acidophilus tablets combined with trimetbutine maleate in the treatment of patients with irritable bowel syndrome with diarrhea. MethodsA total of 103 patients with irritable bowel syndrome with diarrhea were selected as research subjects and randomly divided into a control group (51 cases) or an observation group (52 cases). The control group was treated with trimebutine maleate tablets, based on which the observation group was treated with compound Lactobacillus acidophilus tablets. The clinical efficacy, abdominal pain and diarrhea scores, gastrointestinal hormones levels, intestinal flora numbers, and incidence of adverse reactions were compared between the two groups. ResultsAfter 1 month of treatment, the total effective rate of treatment and the lactobacillus number in the observation group were higher than those in the control group, and the abdominal pain and diarrhea scores, 5-hydroxytryptamin level, neuropeptide Y level, somatostatin level, enterococcus number, and yeast-like fungi number in the observation group were lower than those in the control group (all P＜0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P＞0.05). ConclusionCompound Lactobacillus acidophilus combined with trimebutine maleate can effectively improve the symptoms of patients with irritable bowel syndrome with diarrhea, regulate gastrointestinal hormones, promote the balance of intestinal flora, and with high safety.

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