ObjectiveTo explore the relevance of the helper T(Th) 1/Th2 cells balance and clinical pathological manifestations in IgA nephropathy.MethodsTo evaluate this relevance,we detected the values of Th1 and Th2 in peripheral blood of 40 IgA nephropathy patients and 20 controls by using flow cytometry.Histories of tonsillitis and recurrent attacks of gross hematuria,levels of serum Tch,TG,IgG,IgA,CCr and renal pathology manifestation in IgA nephropathy patients were collected.Then we analyzed the effects of Th1/Th2 balance in IgA nephropathy patients.ResultsCompared with healthy control group,the value of Th2 cells was higher in IgA nephropathy [(1.18±0.15)% vs (1.77±0.90)%,P<0.01].The values of Th1 cells and Th1/ Th2 in the patients with recurrent attacks of gross hematuria were (8.50±4.68)% and 4.10±2.01 respectively,which were significantly higher than those in the controls [(4.04±3.23)% and 2.42±1.50].Compared with the corresponding group,the values of Th1 and Th1/Th2 in IgAN patients with 24-hour urine protein>1.0 g/d was more than those <1.0 g/d (P<0.01).There was a positive correlation between the value of IgG/IgA in serum and the ratio of Th1/Th2 in IgAN.ConclusionThe over-expression of Th2-cell in IgAN may be related with IgA nephropathy immune mechanisms;The Th cell subsets in progresses of gross hematuria and 24-hour urine protein of less than 1.0 g/d show offset of Th1 cells;The value of IgG/IgA in serum has a positive effect on the ratio of Th1/Th2 in IgAN.