ObjectiveTo observe the impact of a regional collaborative rescue system for chest pain center (CPC) under the medical treatment partnerships mode on the efficacy and prognosis of patients with acute ST-elevation myocardial infarction (ASTEMI) treated with primary percutaneous coronary intervention (PPCI). MethodsA total of 181 patients with ASTEMI treated with PPCI were included as research subjects, among which patients who were not transferred by the 120 emergency centers were the control group (n=139), and patients who were transferred from medical institutions within the medical treatment partnerships and by the 120 emergency centers were the observation group (n=42). The quality control indexes of CPC and short-term prognosis were compared between the two groups. ResultsThe time for symptom to first medical contact, symptom to first electrocardiogram, catheterization laboratory activation, symptom to door, symptom to balloon, and door to balloon (D2B) and the incidence of heart failure within 3 months after treatment in the observation group were shorter/lower than those in the control group, and the time for first medical contact to balloon and the D2B attainment rate were longer/higher than those in the control group (all P<0.05). There was no statistically significant difference in in-hospital mortality, in-hospital heart failure incidence, mortality within 3 months after treatment, length of hospital stay, or hospitalization cost between the two groups (all P>0.05). ConclusionThe establishment of a regional collaborative rescue system for CPC under the medical treatment partnerships mode can strengthen pre-hospital first aid, shorten the time for D2B, improve the D2B attainment rate, enhance the rescue capacity and efficiency for patients with ASTEMI, and reduce the incidence of heart failure within 3 months after treatment, which is feasible and effective.