内科

目的观察阻塞性睡眠呼吸暂停低通气（OSAHS）患者经鼻持续气道正压通气（n-CPAP）治疗1个月前后纤维蛋白原（Fbg）和D-二聚体的变化及探讨其临床意义。方法选择我院2010年至2012年收治的157例OSAHS患者，随机分为实验组（85例）和对照组（72例），实验组中睡眠呼吸暂停低通气指数（AHI）中度42例，15＜AHI＜30；重度43例，AHI≥30），经n-CPAP治疗；72例OSAHS患者作为对照组，其中中度38例，15＜AHI＜30；重度34例，AHI≥30，未给予n-CPAP治疗，两组疗程均为1个月，测定治疗前后Fbg及D-二聚体变化，并进行治疗前后及组间比较。结果实验组治疗1个月后Fbg及D-二聚体均比治疗前显著降低（P＜0.01），而对照组这两项指标均无明显变化（P＞0.05）。结论n-CPAP可降低OSAHS患者Fbg及D-二聚体，可能其具有降低心脑血管并发症，改善生活质量的功能。

ObjectiveTo explore the level of fibrinogen (Fbg) and D-dimer in obstructive sleep apnea-hypopnea syndrome (OSAHS) patients before and after nasal continuous positive airway pressure (n-CPAP) treatment for one month,and to discuss their clinical significance.Methods157 OSAHS patients enrolled and treated in our hospital from 2010 to 2012 were recruited,of which 85 (42 moderate cases with 15＜AHI＜30, 43 severe cases with AHI≥30) were selected as the experiment group,while the other 72 (38 moderate cases with 15＜AHI＜30,43 severe cases with AHI≥30) as the control group.The experiment group was exposed to one month of n-CPAP treatment,while no any therapy was applied to the control group.The level of Fbg and D-dimer before and after one month in both groups were measured and compared.ResultsThere was significant decrease of both Fbg and D-dimer level in experiment group after n-CPAP treatment(P＜0.05),while no obvious change of Fbg or D-dimer was observed in control group (P＞0.05).Conclusionn-CPAP could reduce the expression of both Fbg and D-dimer,thus maybe possess the potential of reducing cardiovascular complications and improving quality of life in OSAHS patients.

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