内科

目的总结分析炎症性肠病（IBD）的临床特点，探讨诊治策略。方法对1998年1月至2009年7月354例炎症性肠病住院患者和2003年1月至2009年7月504例炎症性肠病门诊患者资料进行回顾性分析。结果本组资料显示我院近12年来IBD发病呈逐年上升趋势，溃疡性结肠炎（UC）明显多于克罗恩病（CD）。本组IBD患者中男女之比为1.28 ∶1。IBD平均发病年龄（41.07±16.07）岁。UC发病高峰年龄为30～49岁，CD发病高峰年龄为20～39岁。本组住院患者中UC和CD两组民族构成比较无统计学差异。肠镜检查中UC以直肠和乙状结肠病变为主，CD以回盲部及回肠末端病变为主。本组患者IBD病理组织学检出率为41.5%，UC误诊率为17.0%，CD误诊率为25.0%。治疗以氨基水杨酸类及类固醇激素为主。结论炎症性肠发病数呈逐年上升趋势；IBD诊断主要依靠内镜及病理。IBD呈慢性复发性发作过程，应长期维持治疗。

ObjectiveTo summerize and analyze the clinical features of inflammatory bowl disease and explore the diagnosis and treatment strategy.Methods354 cases of in-patients during January 1998 and July 2009 and 504 cases of out-patients from January 2003 to July 2009 were retrospectively analyzed.ResultsOur data showed an ascending trend of IBD in the recent 12 years in our hospital.The patients of UC was significantly more than CD′s,and the ratio of male to female was 1.28 ∶1.The average age of occurrence of IBD was (41.07±16.07),The peak age in UC was 30 to 49 years old,while CD was 20 to 39 years old.There was no statistic difference between the ethnic constituent ratios of in-patients in two groups.The mainly lesion of UC located in rectum and colon sigmoideum,while the lesion of CD mainly located in ileocecal junction and terminal ileum.In our study,the pathological detection rate of IBD was 41.5%.The misdiagnosis rate of UC was 17.0%,while CD was 25.0%.5-aminosalicylate (5-ASA) agents and g1ucocorticoids were the main therapy drugs.ConclusionIBD has an ascending trend in our hospital year by year.Diagnosis of IBD mainly relied on endoscope and pathological examinations.IBD is a chronic process with recurrent episodes,which asks for long-term treatment.