内科

目的探讨中药解郁1号对抑郁症患者血清促肾上腺皮质激素释放因子（CRF）、白细胞介素-2（IL-2）水平的影响。方法将200例抑郁症患者按照随机数字表法随机分为中药组和西药组，中药组服用中药解郁1号，600 g/d，连续服用6周；西药组口服氟西汀，20 mg/d，连续服用6周。采用放射免疫法检测两组患者服药前后血清CRF、IL-2水平并进行比较分析。结果治疗前两组血清CRF、IL-2水平相比，差异无统计学意义（P＞0.05）。经6周治疗后，两组血清CRF水平呈下降趋势，IL-2水平呈升高趋势，与治疗前比较，差异均有统计学意义（P＜0.01）；中药组血清CRF水平低于西药组，差异有统计学意义（P＜0.01）；两组血清IL-2差异无统计学意义（P＞0.05）。结论解郁1号抗抑郁作用机制可能与下调血清CRF、上调血清IL-2水平有关。

ObjectiveTo explore the influences of Jieyu No.1 on Serum CRF and IL-2 levels of patients with depression.Methods200 patients with depression were randomly divided into two groups(Chinese medicine group and Western medicine group).The patients in Chinese medicine group were treated with Jieyu No. 1 600g/d for 6 weeks. The patients in Western medicine group were treated with fluoxetine 20mg/d,for 6 weeks.The serum CRF、IL-2 levels were tested and compared before and after treatment by radio-immunity in each group.ResultsThere were no statistic differences between the two groups of CRF,IL-2 levels before the treatment(P＞0.05);After 6 weeks of treatment,serum CRF decreased and IL-2 increased in two groups,there were significant differences before and after treatment (P＜0.01), and serum CRF in Chinese medicine group was lower than Western medicine group (P＜0.01);there were no significant differences of IL-2 between Chinese medicine group and Western medicine group (P＞0.05).ConclusionsThe mechanism of the anti-depression of Jieyu No.1 maybe concerned with down-regulation of Serum CRF and up-regulation of Serum IL-2 levels.

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