内科

目的评价异基因外周血干细胞移植（Allo-PBSCT）治疗白血病的疗效及移植相关并发症。方法回顾分析9例白血病患者行同胞供者Allo-PBSCT治疗。预处理方案为改良马利兰加环磷酰胺（Bu/CY）；预防移植物抗宿主病（GVHD）采用环孢素A（CSA）加短程甲氨蝶呤（MTX）和霉酚酸酯（MMF）。结果8例患者均获得造血重建，白细胞植活的中位时间为15（13～16）d；1例未植入。出现GVHD 7例，肝静脉闭塞病（HVOD）3例，出血性膀胱炎（HC）1例。中位随访时间为13（0～30）个月6例存活，其中5例为无病存活，3例死亡。结论Allo-PBSCT治疗白血病有效，移植相关并发症可接受。

To explore the clinical effects and complications of allogeneic peripheral blood stem cell transplantation on the treatment of Leukemia.MethodsThe clinical data of 9 patients undergoing allo-PBSCT were analyzed retrospectively.The improved busulfan and cyclophosphamide(Bu/CY) were used as condition pretreatment regimen.Cyclosporine A(CsA) and short-course methotrexate(MTX) and mycophenlate mofetil(MMF) were administered to prevent the graft versus host disease(GVHD).Result8 patients were engrafted successfully,the median time of reconstruct was 15(13～16) days;One patient was not engrafted.Seven patients suffered GVHD and 3 patients suffered hepatic veno-occlusive disease(HVOD) and 1 patient suffered hemorrhagic cystitis(HC).With a median follow-up of 13(0-30)months,six patients (66.7%)were alive, among them,5 patients (55.6%)were disease-free and 3 patients died.ConclusionsAllo-PBSCT is effective in the treatment of leukemia and the complications of transplantation are still acceptable.

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