Objective To explore the linear correlations between thyroid hormones in healthy adults. Methods Thyroid-related data from 1,680 healthy adults were collected. The Pearson correlation analysis was used to explore the linear correlations between thyroid hormones in healthy adults. Results Among the 1,680 healthy adults, the levels of triiodothyronine (T3), tetraiodothyroxine (T4), free triiodothyronine (FT3), and free tetraiodothyroxine (FT4) were normally distributed, while the level of thyroid-stimulating hormone was non-normally distributed. There was no statistically significant difference in the level of T3, T4, FT3, or FT4 between men and women or between different age groups (all P>0.05). The Pearson correlation analyses results showed that there were linear correlations between FT3 and T3 levels and between FT3 and FT4 levels in healthy adults, both of which were positively correlated (all P<0.05). The FT3 and T3 levels presented a weak correlation, and an FT3/FT4 ratio ranging from 0.20 to 0.32 was considered to be normal in adults. Conclusion There are linear correlations between thyroid hormones (FT3 and T3, FT3 and FT4) in healthy adults, and the FT3/FT4 ratio has specific patterns in different thyroid diseases, which can be a research target in clinical disease research. The FT3/FT4 ratio has certain reference significance for the clinical differential diagnosis of thyroid diseases.

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