ObjectiveTo explore the clinical significance of serum homocysteine（Hcy） and C-reactive protein（CRP）in diabetic nephropathy（DN）.MethodsAccording to the results of urinary albumin excretion rate,103 patients with type 2 diabetes mellitus were divided into simple diabetic mellitus group (SDM group),early diabetic nephropathy (EDN group) and clinical diabetic nephropathy (CDN group).And thirty healthy people were enrolled as control group.Plasma Hcy and CRP were detected.ResultsHcy、CRP in SDM group、EDN group and CDN group were all significantly higher than that of control group (all P＜0.05).The levels of SDM group,EDN group and CDN group increased successively.Significant differences existed between SDM group、EDN group and CDN group(all P＜0.05).ConclusionIncreased Hcy and CRP might be related to the progression of DN.They could be used as the pathogenetic condition monitoring indexes for diabetic nephropathy.

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