内科

目的观察α硫辛酸治疗糖尿病周围神经病变的疗效。方法选择126例糖尿病周围神经病变患者，随机分成三组，每组42例。A组给予单用甲钴胺治疗，B组给予单用α硫辛酸治疗，C组给予α硫辛酸和甲钴胺联合治疗，疗程均为2周。观察三组治疗后的临床疗效及神经传导速度（NCV）。结果治疗后三组临床疗效比较，差异有统计学意义（H=12.175，P=0.02）。B组和C组疗效优于A组（P＜0.05）；三组治疗后神经传导速度均显著提高，C组有效率最高，但C组和B组无统计学差异。结论α硫辛酸能有效改善糖尿病周围神经病变的症状和神经传导速度。

ObjectiveTo observe the therapeutic effect of α lipoic acid on diabetic peripheral neuropathy(DPN).Methods126 patients with diabetic peripheral neuropathy were randomly divided into three groups (each group 42 cases).Group A were treated by mecobalamin,Group B were treated byαlipoic acid,Group C were treated by combination of αlipoic acid and mecobalamin.The treatment courses were 2 weeks for every group.The therapeutic effect and nerve conduction velocity(NCV) of the three groups were observed at the end of treatment.ResultsThere were statistic differences between therapeutic effects of 3 groups after treatment(H=12.175,P=0.02).The therapeutic effects of both Group B & C are better than Group A(P＜0.05);After treatment,the nerve conduction velocity were all significantly improved and Group C is the most effective one,but there is no statistical difference between Group C & B.Conclusionsα lipoic acid can effectively improve the symptoms and nerve conduction velocity of DPN patients.

ref