Objective To investigate the effect of Dingkundan combined with intrauterine perfusion of autologous platelet-rich plasma (PRP) treatment on patients with thin endometrium. Methods A total of 60 patients with thin endometrium were selected as research subjects and randomly divided into the control group or the study group, with 30 cases in each group. The control group was given intrauterine perfusion of autologous PRP treatment, based on which the study group was treated with Dingkundan additionally. The total effective rate of treatment, as well as uterine artery blood flow parameters, endometrial thickness, serum factors levels before and after treatment, and the incidence of adverse reactions during treatment were compared between the two groups. Results After treatment, the total effective rate of treatment, endometrial thickness, serum levels of platelet‑derived growth factor-AB, platelet‑derived growth factor-BB, vascular endothelial growth factor, and transforming growth factor-β1 in the study group were higher/greater than those in the control group, and the uterine artery pulsatility index, uterine artery blood flow resistance index, and uterine artery systolic peak blood flow velocity/end diastolic velocity were lower than those in the control group (all P<0.05). During treatment, the total incidence of adverse reactions in the study group was lower than that in the control group (P<0.05). Conclusion Dingkundan combined with intrauterine perfusion of autologous PRP treatment can improve uterine artery blood flow and endometrial thickness in patients with thin endometrium and increase their serum cell growth factors expression levels, with mild adverse reactions.

无