Objective To investigate the clinical features of AIDS patients complicated with cryptococcal bloodstream infection. Methods The clinical data of 22 hospitalized AIDS patients complicated with cryptococcal bloodstream infection were retrospectively analyzed, including clinical manifestations, laboratory and cerebrospinal fluid examinations and drug susceptible test results, treatment, and prognosis. Results Among the 22 AIDS patients, 5 cases were complicated with cytomegalovirus infection, 5 cases were complicated with pulmonary tuberculosis, 4 cases were complicated with Pneumocystis pneumonia, and 12 cases were complicated with cryptococcal meningitis. Their clinical manifestations included fever, headache, nausea and vomiting, cognitive impairment, and decreased visual acuity. The laboratory examinations results showed that 22 cases had CD4+ T lymphocyte counts < 100/μL. The cerebrospinal fluid examinations results showed 9 cases (75%) had cerebrospinal fluid pressure ≥200 mmHg, 3 (25%) had turbid cerebrospinal fluid, 6 (50%) had decreased cerebrospinal fluid glucose levels, 7 (58%) had decreased cerebrospinal fluid chloride levels, and 7 (58%) had increased cerebrospinal fluid protein levels. Results of drug susceptible tests showed that 21 cases were sensitive to amphotericin B, itraconazole, voriconazole, fluconazole, and flucytosine, and 1 case was resistant to amphotericin B. After treatment, 3 cases (14%) improved, 7 cases (32%) died, and 12 cases (55%) were lost to follow-up after giving up treatment. Conclusion AIDS complicated with cryptococcal bloodstream infection often occurs in patients with a CD4+ T lymphocyte count of <100/μL, who are usually sensitive to amphotericin B, itraconazole, voriconazole, fluconazole, and flucytosine, and are prone to cryptococcal meningitis, with poor treatment response and high mortality.  

无