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芪黄复荣汤治疗糖尿病下肢周围血管病变患者的效果及其对下肢微循环和血管生长因子的影响
Effect of Qihuang Furong decoction in the treatment of lower extremity peripheral vascular disease patients with diabetes and its impacts on lower extremity microcirculation and vascular growth factors

内科 202318卷05期 页码:435-438+473

作者机构:河南省鹤壁市中医院脾胃肝胆糖尿病科,鹤壁市458030

DOI:10.16121/j.cnki.cn45-1347/r.2023.05.07

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目的 探讨芪黄复荣汤治疗糖尿病下肢周围血管病变患者的效果及其对下肢微循环和血管生长因子的影响。方法 选取108例糖尿病下肢周围血管病变患者作为研究对象,随机将其分为对照组、观察组,每组54例。对照组行常规治疗,观察组在对照组基础上增加芪黄复荣汤治疗,两组均治疗4周。比较两组患者的临床疗效、中医证候积分、下肢微循环指标、血管生长因子和内皮祖细胞水平。结果 治疗4周后,观察组患者总有效率高于对照组,下肢疼痛、下肢发凉、下肢麻木、下肢感觉减退症候评分均低于对照组,胫后动脉收缩期最大血流速度、足背动脉收缩期最大血流速度、胫后动脉内径、足背动脉内径,血清血管内皮生长因子、碱性成纤维细胞生长因子、血小板源性内皮细胞生长因子水平,以及外周血单核细胞内皮祖细胞水平均高/大于对照组(均P<0.05)。结论 芪黄复荣汤配合常规治疗能够有效地减轻糖尿病下肢周围血管病变患者的临床症状,改善下肢微循环,促进血管生长,提高治疗效果。

Objective To investigate the effect of Qihuang Furong decoction in the treatment of lower extremity peripheral vascular disease patients with diabetes and its impacts on lower extremity microcirculation and vascular growth factors. Methods A total of 108 lower extremity peripheral vascular disease patients with diabetes were selected as research subjects and randomly divided into a control group or an observation group, with 54 cases in each group. The control group was treated routinely, based on which the observation group was treated with Qihuang Furong decoction, and both groups were treated for 4 weeks. The clinical efficacy, traditional Chinese medicine syndromes scores, lower extremity microcirculation indexes, and levels of vascular growth factors and endothelial progenitor cells of the two groups were compared. Results After 4 weeks of treatment, the total effective rate of patients in the observation group was higher than that of the control group, and the scores of lower extremity pain, lower extremity coldness, lower extremity numbness, and lower extremity hypoesthesia syndromes were lower than those of the control group, and the maximum systolic blood flow velocity of posterior tibial artery, maximum systolic blood flow velocity of dorsal pedis artery, inner diameter of the posterior tibial artery, inner diameter of the dorsal pedis artery, and serum levels of vascular endothelial growth factor, alkaline fibroblast growth factor, and platelet-derived endothelial cell growth factor, as well as endothelial progenitor cells level in peripheral blood mononuclear cells, were higher/larger than those of the control group (all P<0.05). Conclusion Qihuang Furong decoction combined with routine treatment can effectively relieve the clinical symptoms of lower extremity peripheral vascular disease patients with diabetes, improve lower extremity microcirculation, promote the growth of blood vessels, and improve the treatment effect.

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