Objective To investigate influencing factors for immunosuppressant therapy ineffectiveness in patients with lupus nephritis (LN). Methods The clinical data of 116 LN patients treated with immunosuppressants were retrospectively analyzed, and according to the therapeutic effects, the LN patients who did not achieve remission, with renal failure, or of clinical death were classified as the ineffective group (n=26), and LN patients with complete remission or partial remission were classified as the effective group (n=90). The general data, laboratory indexes, and pathological characteristics indexes of the two groups were compared, and the multivariate logistic regression model was used to analyze the influencing factors for immunosuppressant therapy ineffectiveness in LN patients. Results The renal damage course, serum creatinine level, triglyceride level, urine protein level, uric acid level, proportion of patients with grade Ⅲ-Ⅴ pathological type, proportion of patients with moderate and severe chronic lesions in renal interstitium, chronic index, proportion of patients with glomerulosclerosis, and proportion of patients with hematuria were longer/higher than those in the effective group, while the urine output and levels of CD3+ cells, CD4+ cells, and CD8+ cells were lower in the ineffective group than in the effective group (all P<0.05). The results of multivariate logistic regression model analysis showed that a long renal damage course, a high serum creatinine level, hematuria, a high urine protein level, and grade Ⅲ-Ⅴ pathological type were risk factors for immunosuppressant therapy ineffectiveness in LN patients (all P<0.05). Conclusion A long renal damage course, a high serum creatinine level, hematuria, a high urine protein level, and grade Ⅲ-Ⅴ pathological type are risk factors for immunosuppressant therapy ineffectiveness in LN patients, and targeted intervention on the abovementioned factors may improve the clinical effect of immunosuppressant therapy.

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