ObjectiveTo investigate the correlation between the plasma homocysteine (Hcy) level and colorectal carcinoma. MethodsA total of 81 patients with colorectal carcinoma (colorectal carcinoma group), 52 patients with dysplastic colorectal polyps (dysplastic colorectal polyps group), and 54 patients with dysplasia-free colorectal polyps (dysplasia-free colorectal polyps group) were enrolled as research objects. The plasma Hcy levels of the three groups were compared, the binary logistic regression model was used to analyze the influencing factors for the incidence of colorectal carcinoma, and the receiver operating characteristic (ROC) curve was drawn to evaluate the value of the plasma Hcy level in predicting the incidence of colorectal carcinoma. ResultsThe plasma Hcy level in the colorectal carcinoma group was higher than that in the dysplasia-free colorectal polyps group and the dysplastic colorectal polyps group (all P＜0.05), and the plasma Hcy level was an independent influencing factor for the incidence of colorectal carcinoma (P＜0.05). The results of the ROC curve analysis showed that the area under the ROC curve of plasma Hcy level for predicting colorectal carcinoma was 0.614, and the optimal cut-off value was 15.25 μmol/L (sensitivity and specificity were 50.0% and 71.4%, respectively). ConclusionsThe plasma Hcy level in colorectal carcinoma patients is significantly increased, and the elevated plasma Hcy level is an independent risk factor for the incidence of colorectal carcinoma.

无