Objective To investigate the correlations of vitamin A and vitamin E levels with wheezing disease in children. Methods A total of 234 children with wheezing disease were selected as the wheezing group, while 244 children undergoing healthy physical examinations were selected as the control group. The vitamin A and vitamin E levels were compared between the two groups, and their correlations with lung function in the wheezing group were analyzed with Pearson or Spearman correlation. Results The vitamin A level and the proportion of children with normal vitamin A levels in the wheezing group were lower than those in the control group, and the proportions of children with subclinical vitamin A deficiencies and children with suspected subclinical vitamin A deficiencies were higher than those in the control group (all P<0.05). The vitamin E level and the proportion of children with normal vitamin E levels in the wheezing group were lower than those in the control group, and the proportions of children with vitamin E deficiencies and children with vitamin E insufficiencies were higher than those in the control group (all P<0.05). The results of Pearson correlation analysis showed that there was no correlation between the vitamin A level and ratio of time to peak tidal expiratory flow to total expiratory time, volume at peak tidal expiratory flow, fractional exhaled nitric oxide (FeNO), immunoglobulin (Ig)E, IgG, or the absolute value of peripheral blood eosinophils (EOS) (all P>0.05). There was no correlation between the vitamin E level and ratio of time to peak tidal expiratory flow to total expiratory time, volume at peak tidal expiratory flow, IgE, IgG, or the absolute value of peripheral blood EOS (all P>0.05), but there was negative correlation between the vitamin E level and FeNO (P<0.05). Conclusion Vitamin A and vitamin E levels in children with wheezing disease are relatively low, and their vitamin E levels are negatively correlated with FeNO.

无