内科

目的探讨奥扎格雷钠联合依达拉奉治疗急性脑梗死的临床疗效及安全性。方法将急性脑梗死患者140例随机分为联合组和对照组各40例。对照组行常规治疗：口服阿司匹林，静滴奥扎格雷钠、胞二磷胆碱等；联合组在对照组用药基础上同时给予依达拉奉静滴。两组疗程均为14 d。治疗前、治疗后第3天、第7天、第14天对两组患者进行神经功能缺损（NIHSS）评定、临床疗效评价和日常生活能力（Barthel指数，BI）评分，并监测凝血常规、肝肾功能、血脂、血糖和心电图。结果联合组临床疗效优于对照组；两组患者治疗后NIHSS评分和BI评分均有明显改善；治疗后第3天、第7天和第14天联合组的改善程度均优于对照组，差异均有统计学意义（P＜0.05）。结论奥扎格雷钠联合依达拉奉治疗急性脑梗死临床效果显著、安全，能明显改善患者的神经功能缺损。

ObjectiveTo investigate the effectiveness and safety of Ozagrel sodium combined with Edaravone in patients with acute cerebral infarction(ACI).Methods140 cases with ACI were randomly divided into combination group and control group,70 cases respectively.Conventional therapy was conducted in control group,such as aspirin,Ozagrel Sodium and cytidine diphosphate choline.Edaravone was added in the combination group on the basic therapy of control group.The course of treatment in two groups both are 14 days.NIHSS examination,efficacy evaluation and BI assessment were conducted at the time before treatment,3 days,7 days and 14 days after treatment.At the same time,coagulation function,liver function,kidney function,blood fat,glucose and electrocardiogram were checked.ResultsThe clinical curative effect of combination group is better than the control group.The NIHSS and BI of the two groups were improved obviously.The improvement of NIHSS and BI in combination group are better than control group at the time of 3 days,7 days,and 14 days after treatment(P＜0.05).ConclusionOzagrel sodium combined with Edaravone is effective and safe in ACI patients and can improve their impairment of nerve function.

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