内科

目的应用血管回声跟踪技术及脉搏波速度测定系统观察辛伐他汀临床干预对高血压患者颈动脉内膜的影响。方法采用随机数分配法将120例高血压患者分为观察组60例，对照组60例，并选取健康体检者30人为血压健康组，观察高血压组与血压健康组的颈动脉内膜差异。对照组给予服用钙离子拮抗剂、血管紧张素转换酶抑制剂、利尿剂等常规降压治疗，观察组在常规降压治疗的基础上，加服辛伐他汀20 mg，1次/d，2个月后，对比两组治疗前后颈动脉内膜指标差异。结果观察组、对照组颈动脉内膜各项指标与血压健康组比较，差异均有统计学意义（P＜0.05）；治疗2个月后，观察组颈动脉内膜各项指标改善程度明显优于对照组（P＜0.05）。结论辛伐他汀对高血压患者颈动脉内膜有着显著的干预作用。

ObjectiveTo apply vascular echo tracking technology and pulse wave velocity determination system to observe the influence of clinical intervention of simvastatin on carotid endarterium of patients with hypertension.Methods120 patients with hypertension were divided into observation group(60 cases) and control group(60 cases),then 30 health people as normal blood pressure group.The differences of carotid endarterium of the normal blood pressure group and the hypertension group was observed.The control group was treated by conventional antihypertensive therapy,such as calcium antagonists,angiotensin converting enzyme inhibitors,diuretics.The observation group were added 20 mg simvastatin on the basis of conventional treatment,once per day.Two months later,the carotid endarterium index were compared between two groups before and after treatment.ResultsThere are significant differences of carotid endarterium index between observation group,control group and the normal blood pressure group(P＜0.05).Two months after treatment,the improvement of carotid endarterium index of observation group was obvious superior than control group (P＜0.05).ConclusionSimvastatin had a significant role in the intervention to carotid endarterium of patients with hypertension.

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