ObjectiveTo investigate the correlation between serum homocysteine level and Parkinson′s disease (PD).And observed efficacy of vitamins B and entacapone in the treatment of levodopa-induced hyperhomocysteinemia.Methods90 patients with PD and 90 cases of normal elderly group matching with ages and sexual were recruited in this study.Serum homocysteine,vitamin B12 and folate levels of all cases were detected.90 PD patients were randomly divided into 3 groups using random number table method,then respectively treated with placebo,vitamins B(VB12 1 mg/d、folate 500μg/d) and entacapone 200 mg daily.Serum Hcy level of three groups were checked before and after treatment.ResultsThe serum Hcy level of all groups were significantly different(F=25.580,P=0.001).The Hcy levels of PD group were significantly higher than the normal elderly group (P＜0.05).Plasma Hcy levels of PD patients treatment with levodopa group was significantly higher than the untreated and non-L-dopa treatment PD group (P＜0.05). Folate levels of PD group was lower than that of the normal elderly group(P＜0.05).VB12,folate and entacapone could reduce serum Hcy levels of PD patients(P＜0.05). Serum Hcy levels were negatively correlated with folate levels(r=-0.425,P＜0.05).ConclusionsHyperhomocysteinemia may be a risk factor for Parkinson′s disease, and connect with the lack of vitamins B and treatment with levodopa. Vitamins B and entacapone may reduce levodopa-indued hyperhomocysteinemia.

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